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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (6): 677-681.

• 研究原著 • 上一篇    下一篇

尿多酸肽对乳腺癌细胞增殖的抑制作用

王艳红, 郑伟1   

  1. 解放军总医院第一临床药局, 1普外科, 北京100853
  • 收稿日期:2005-05-31 修回日期:2005-06-13 出版日期:2005-06-26 发布日期:2020-11-12
  • 通讯作者: 王艳红, 女, 药师, 主要从事临床药物与药理的研究。Tel:(0) 13901280229 E-mail: mailforljq@yahoo.com.cn

Effects of uroacitides on proliferation ability of breast cancer cells

WANG Yan-hong, ZHENG Wei   

  1. The First ClinicalMedicine Bureau, Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China
  • Received:2005-05-31 Revised:2005-06-13 Online:2005-06-26 Published:2020-11-12

摘要: 目的: 研究尿多酸肽(CDA-II) 对乳腺癌细胞增殖的抑制作用。方法: 将CDA-II 与乳腺癌细胞株MCF-7 和MDA-MB-231 进行体外培养, 观察CDA-II对乳腺癌细胞生长曲线及形态学等方面的影响。结果: CDA-II 对两种不同生物特征的乳腺癌细胞株ER+MCF-7 细胞和ER-MDA-MB-231 细胞生长和增殖均有不同程度的抑制作用, 而且其生长抑制作用在一定时间和剂量范围内, 呈剂量依赖性;形态上,加CDA-II 培养后, 细胞体积增大, 生长密度稀疏, 细胞间隙拉宽, 胞质增多, 核/质比例下降, 核仁小而少, 细胞固缩、退变。结论: CDA-II 可抑制不同生物学特性的两株乳腺癌细胞的生长和增殖。

关键词: 乳腺癌, 尿多酸肽(CDA-II), 维甲酸, 细胞培养

Abstract: AIM: To investigate the growth inhibition effects of CDA-II on breast cancer cells. METHODS: The effects of CDA-II on growth curve and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed in vitro cultures. RESULTS: CDA-II reduced the growth speed and proliferation ability. CONCLUSION: CDA-II has remarkable effects on anti-cellproliferation and shows good prospects of application in the treatment of patients with breast carcinoma.

Key words: breast carcinoma, uroacitides (CDAII), retinoic acid, cell culture

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