血管内皮细胞非神经性乙酰胆碱系统的研究进展

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (3): 254-258.

血管内皮细胞非神经性乙酰胆碱系统的研究进展

陈凯, 汪海

军事医学科学院毒物药物研究所, 北京100850

收稿日期:2005-01-31 修回日期:2005-03-14 出版日期:2005-03-26 发布日期:2020-11-18
通讯作者: 汪海, 男, 研究员, 博士, 研究方向:心血管药理学。Tel:010-66932651 E-mail:wh@nic.bmi.ac.cn
作者简介:陈凯, 男, 助理研究员, 博士生, 研究方向:分子心血管药理学。Tel:010-66931557 E-mail:chenkai@bbn.cn
基金资助:
国家“973” 重点基础研究发展规划项目(NoG1998051112);北京赛德维康医药研究院新药研究基金资助项目(No1999001)

Research progress of non-neuronal acetylcholine systems in endothelium

CHEN Kai, WANG Hai

Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, China

Received:2005-01-31 Revised:2005-03-14 Online:2005-03-26 Published:2020-11-18

摘要/Abstract

摘要： 血管内皮细胞作为人体主要的代谢库, 存在ACh, 并伴有ChAT 的表达, 有机阳离子载体(OCTs)参与血管内皮细胞ACh 的转运和释放, 血管内皮细胞AChE 活性的广泛表达可以使非神经性ACh 的活性仅仅局限于它的合成和释放区域, 成为一种细胞因子。mAChR 和nAChR 同非神经性ACh 一样, 广泛存在于血管内皮细胞中, ACh 通过其受体发挥重要的病理生理功能。nAChR 参与血管内皮细胞多种生物活性物质的分泌和释放, 其中α₇ 受体在血管新生中发挥重要作用。非神经性ACh 诱发内皮依赖的血管舒张反应, 一种不同于神经性mAChR 的血管内皮细胞非神经性M 受体在其中发挥重要作用, 并且在动脉粥样硬化和血栓的发生发展过程中起着重要的作用。

关键词: 非神经性乙酰胆碱, 内皮细胞, 血管新生, 动脉粥样硬化, 血栓

Abstract: ACh widely distributes in non-nervous tissues and cells.The organic cation transporters (OCTs) are involved in the transportation and release of ACh. Wide expressions of AChE in endothelium limit the effects of non-neuronal acetylcholine on the area of its synthesis and release and it makes the non-neuronal acetylcholine be a cytokine.Muscarinic and nicotinic receptors are widely expressed on endothelial cells in comparison with the distribution of non-neuronal acetylcholine.Nicotinic receptors are involved in the synthesis and release of several bioactivity molecules.The α₇ subtype of nicotinic receptors participates in the angiogenesis.Non-neuronal acetylcholine induces the vascular relaxation with intact endothelium.The endothelial target for acetylcholine different from neuronal acetylcholine receptors plays an important role in vascular relaxation, and participates in the progress of atherosclerosis and thrombosis.

Key words: non-neuronal acetylcholine, endothelium, angiogenesis, atherosclerosis, thrombosis

中图分类号:

R966

陈凯, 汪海. 血管内皮细胞非神经性乙酰胆碱系统的研究进展[J]. 中国临床药理学与治疗学, 2005, 10(3): 254-258.

CHEN Kai, WANG Hai. Research progress of non-neuronal acetylcholine systems in endothelium[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(3): 254-258.

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