欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (6): 655-658.

• 研究原著 • 上一篇    下一篇

氯沙坦、卡托普利对心功能不全患者血清地高辛浓度及疗效的影响

谢守霞, 张万帆, 董少红, 曾繁典1   

  1. 暨南大学医学院附属第二医院、深圳市人民医院,深圳 518020,广东;
    1华中科技大学同济医学院临床药理研究所,武汉 430030,湖北
  • 收稿日期:2003-07-15 修回日期:2003-07-28 出版日期:2003-12-26 发布日期:2020-11-19
  • 通讯作者: 谢守霞,女,硕士,副主任药师,主要从事医院药学工作。Tel:0755-25534466 Fax:0755-25536506 E-mail:szzwf2000@yahoo.com.cn
  • 作者简介:曾繁典,男,教授,博士生导师,研究方向:临床药理和心血管药理。

Effects oflosartan and captopril on serum digoxin concentration and efficacy inPatients with heart failure

XIE Shou-Xia, ZHANG Wang-Fan, DONG Shao-Hong, ZENG Fan-Dian1   

  1. Department ofPharmacy,The Second Hospital of Jinan University,ThePeople' s Hospital of Shenzhen,Shenzhen 518020,Guandong,China;
    1Institute of ClinicalPharmacology,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,Hubei,China
  • Received:2003-07-15 Revised:2003-07-28 Online:2003-12-26 Published:2020-11-19

摘要: 目的 观察氯沙坦及卡托普利对心功能不全患者血清地高辛浓度及疗效的影响。方法 28 例心功能Ⅱ ~Ⅳ级的充血性心力衰竭患者每天口服地高辛0 .25 mg,1 wk 后当血清地高辛浓度达稳态后,随机分为氯沙坦组和卡托普利组。氯沙坦组加服氯沙坦50 mg,qdⅸ4 wk;卡托普利组加服卡托普利25 mg,tidⅸ4 wk 。于合用前及合用后第1 周、第4周测定血清地高辛浓度,并观察临床疗效。结果 氯沙坦并不增加地高辛稳态血清浓度,卡托普利增加地高辛稳态血清浓度29 .6%;两药均可增加左室射血分数,减慢心率,降低血压,总有效率分别为92 .9%、85 .7%,对血钾、血肌酐无明显影响,氯沙坦组耐受性高于卡托普利组。结论 氯沙坦与地高辛联合应用治疗心功能不全患者是安全的,并能改善患者心脏功能,其耐受性优于卡托普利;卡托普利与地高辛联合应用时应密切监测血清地高辛浓度。

关键词: 药效学, 氯沙坦, 卡托普利, 地高辛, 心功能不全, 血清浓度

Abstract: AIM: To observe the effects of angiotensin receptor antagonistlosartan and angiotensin converting enzyme inhibitor captopril on serum digoxin concentrations and clinical efficacy in thePatients with heart failure.METHODS: Twenty-eightPatients with NYHA classⅡ-Ⅳ heart failure were randomly assigned tolosartan grouPand captopril group,were treated with digoxin 0.25 mg(Po,qd)for 1 wk.And then followed by 4wk combination withlosartan(50 mg,po,qd)or captopril(25 mg,po,tid).The serum digoxin concentrations and clinical features were monitored and measured.RESULTS: Losartan did not increase the steady statelevel of serum digoxin,but captopril could increase serum digoxin concentrations by 29.6%;both groups had the effects of increasinglVEF,reducing heart rate,decreasing bloodPressure,the total clinical effective rates oflosartan grouPand captopril grouPwere 92.9% and 85.7%,respectively.The serumPotassium and creatinine were unchanged.The compliance inlosartan grouPwas better than that in captopril group.CONCLUSION: Bothlosartan and captopril were effective in treatment ofPatients with heart failure.The co-administration of digoxin withlosartan was safe.The digoxin concentrations should be monitored in combination with captopril.

Key words: pharmacodynamics, losartan, captopril, digoxin, serum concentration, heart failure

中图分类号: