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中国临床药理学与治疗学 ›› 2019, Vol. 24 ›› Issue (2): 188-191.doi: 10.12092/j.issn.1009-2501.2019.02.011

• 临床药理学 • 上一篇    下一篇

汉族人群ABCB13435C/T和2677T/G基因多态性对地高辛血清浓度的影响

江 慧,苗 苗,徐文科   

  1. 皖南医学院弋矶山医院药学部,芜湖 241001,安徽
  • 收稿日期:2018-09-05 修回日期:2019-01-31 出版日期:2019-02-26 发布日期:2019-03-04
  • 通讯作者: 徐文科,男,副主任药师,研究方向:临床药学和药事管理。 E-mail: 1447486817@qq.com
  • 作者简介:江慧,女,主管药师,学士学位,研究方向:临床药学和药事管理。 Tel:13003048658 E-mail:1941593061@qq.com
  • 基金资助:

    皖南医学院中青年项目自然科学类(WK2017F14,WK2018F09)

Effects of ABCB13435C/T and 2677T/G gene polymorphisms on serum concentration of digoxin in Han population

JIANG Hui,MIAO Miao,XU Wenke   

  1. Department of Pharmacy,Yijishan Hospital of Wannan Medical College,Wuhu 241001,Anhui,China
  • Received:2018-09-05 Revised:2019-01-31 Online:2019-02-26 Published:2019-03-04

摘要:

目的: 研究ABCB1基因多态性对地高辛血清浓度的影响。方法: 选择2016年1月-12月接受地高辛治疗慢性充血性心力衰竭患者。采用荧光染色原位杂交分析技术对患者进行ABCB13435C/T和2677T/G基因分型。所有患者采用地高辛0.125 mg/d的给药方案,连续服用5 d后,采用荧光偏振免疫法检测地高辛血清谷浓度。比较ABCB13435C/T和2677T/G不同基因型患者地高辛血清浓度的差异。结果: 纳入93例患者,ABCB13435C/T和2677T/G基因突变率分别为38.17%和28.49%,且男女之间基因分布频率未见明显差异。与3435CC/CT和2677TT/TG基因型患者比较,3435TT和2677GG型地高辛血清浓度明显升高(P<0.001)。结论: ABCB1基因多态性可影响地高辛血清浓度,但需临床进一步验证。

关键词: ABCB1, 地高辛, 血清浓度, 基因多态性, 个体化用药

Abstract:

AIM: To investigate the effect of ABCB1 gene polymorphism on serum concentration of digoxin. METHODS: Patients with chronic congestive heart failure who received digoxin treatment from January to December 2016 were selected. ABCB13435C/T and 2677T/G genotyping were performed on patients by fluorescence staining in situ hybridization analysis. All patients were treated with digoxin 0.125 mg/daily,5 days after continuous use,fluorescence polarization immunoassay was used to detect digoxin serum valley concentration.To compare the differences of digoxin serum concentrations in patients with different genotypes of ABCB13435C/T and 2677T/G. RESULTS:In 93 patients,the mutation rates of ABCB13435C/T and 2677T/G genes were 38.17% and 28.49% respectively,and there was no significant difference in gene distribution frequency between male and female.Compared with 3435CC/CT and 2677TT/TG genotype patients, the serum concentrations of 3435TT and 2677GG digoxin increased significantly (P<0.001). CONCLUSION: ABCB1 gene polymorphism can affect digoxin serum concentration,but it needs further clinical validation.

Key words: ABCB1, digoxin, serum concentration, gene polymorphism, individual medication

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