欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (5): 551-554.

• 研究原著 • 上一篇    下一篇

不同产品非洛地平缓释片药物动力学比较

梁竹, 王宝德1, 于燕莉, 谢继青, 芦怀平, 袁成   

  1. 济南军区总医院药学部, 济南 250031, 山东;
    1德州联合医院内科, 德州 253014, 山东
  • 收稿日期:2004-07-19 修回日期:2005-03-01 出版日期:2005-05-26 发布日期:2020-11-19
  • 通讯作者: 袁成,男, 本科, 主任药师, 研究方向:临床药理学。Tel:0531-2165173 E-mail:chengyuan90@163.com
  • 作者简介:梁竹, 女, 本科, 副主任药师, 研究方向:医院药学。Tel:0531-2166860  E-mail:lyzc@eyou.com

Pharmacokinetics of different felodipine sustained-release tablets in healthy volunteers

LIANG Zhu, WANG Bao-de1, YU Yan-li, XIE Ji-qing, LU Huai-ping, YUAN Cheng   

  1. Department of Pharmacy, General Hospital of Jinan Military, Jinan 250031, Shandong, China;
    1Department of Internal Medicine, DezhouUnion Hospital, Dezhou253014, Shangdong, China
  • Received:2004-07-19 Revised:2005-03-01 Online:2005-05-26 Published:2020-11-19

摘要: 目的: 比较几种国产非洛地平缓释片在体内的药物动力学和生物利用度。方法: 用高效液相色谱测定口服药物后血浆药物浓度, 以普通非洛地平片作为参照, 计算药物动力学和生物利用度。结果: 在 0.5~ 10 μg°L-1范围内, 非洛地平血浆药物浓度与色谱峰高呈现良好线性相关。单剂量人血浆中非洛地平缓释片动力学参数在不同产品存在差别, 相对于普通制剂的生物利用度分别为 168%、177%和125%。结论: 不同产品非洛地平缓释片药物动力学和生物利用度存在差别。

关键词: 非洛地平, 缓释片, 药物动力学, 生物利用度, 高效液相色谱

Abstract: AIM: To compare pharmacokinetics and bioavailability of different felodipine sustained-release tablets in healthy volunteers.METHODS: Drug concen-trations were determined in plasma following a single oral dose of 5 mg felodipine sustained-release tablets by high performance liquid chromatography method. Referenced with the general felodipine tablets, pharmacokinetics and bioavailability were calculated and compared. RESULTS: Good linear relationship between felodipine con-centration was obtained at ranges of 0.5 -10μg°L-1 in plasma and the peak-high.Pharmacokintic parameters were different clearly for different felodipine sustained-re-lease tablets in healthy volunteers, and bioavailability ref-erenced with the general felodipine tablets were 168%, 177%and 125%, respectively. CONCLUSION: There are difference at pharmacokintics and bioavailability among those three felodipine sustained-release tablets.

Key words: felodipine, sustained-release tablets, pharmacokinetics, bioavailability, high performance liquid chromatography

中图分类号: