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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (1): 100-103.

• 研究原著 • 上一篇    下一篇

福辛普利对平滑肌细胞凋亡及凋亡调控基因的影响

梁绪国, 吕志军1   

  1. 青岛大学医学院附属烟台毓璜顶医院心内科, 烟台 264000, 山东;
    1烟台中医院心电图室, 烟台 264001, 山东
  • 收稿日期:2004-10-21 修回日期:2004-12-10 出版日期:2005-01-26 发布日期:2020-11-19
  • 通讯作者: 梁绪国, 医学博士, 主任医师, 教授, 硕士研究生导师, 主要从事冠心病发病机理、药物治疗及介入诊疗工作。Tel:0535-6258009 E-mail:liangxuguo@yahoo.com.cn
  • 基金资助:
    山东省科技攻关计划项目(No032050114)

Effects of fosinopril on apoptosis and apoptosis genes in vascular smooth muscle cells

LIANG Xu-guo, LV Zhi-jun1   

  1. Department of Cardiology, Yantai Yuhuangding Hospital, Medical College, Qingdao University, Yantai 264000, Shangdong, China;
    1Department of Electrocardiographic, Yantai Traditional Chinese Medicine Hospital, Yantai264001, Shangdong, China
  • Received:2004-10-21 Revised:2004-12-10 Online:2005-01-26 Published:2020-11-19

摘要: 目的: 探讨血管紧张素II 在不同浓度和不同作用时间下对血管平滑肌细胞凋亡及凋亡调控基因表达的作用, 并研究福辛普利对其的影响。方法: 采用流式细胞技术测定在不同浓度和不同作用时间血管紧张素II 作用下血管平滑肌细胞凋亡率及凋亡调控基因Fas、Bcl-2 表达的变化和福辛普利对其的影响。结果: 血管紧张素II 对血管平滑肌细胞凋亡和凋亡调控基因表达有较明显的诱导作用。福辛普利可抑制AngII 作用, 对细胞凋亡有一定的影响, 同时可影响凋亡调控基因的表达。结论: 血管紧张素II 具有一定的的促进血管平滑肌细胞凋亡作用和调节凋亡调控基因表达的作用, 尤其大剂量作用较明显。而福辛普利可明显抑制AngII 对血管平滑肌细胞的作用。

关键词: 血管紧张素II, 血管平滑肌细胞, 细胞凋亡, 凋亡调控基因, 福辛普利

Abstract: AIM: To investigate the effects of angiotensin II (AngII) in different concentrations and different action times on the rate of apoptosis and expression of apoptosis genes in vascular smooth muscle cells and the influences of fosinopril on it.METHODS: Flow cytometer was used to measure the apoptosis rate and the expression of apoptosis genes (Fas and Bcl-2) induced by AngII in different concentrations and different action times and the influence caused by fosinopril.RESULTS: The rate of apoptosis and the expression of apoptosis genes were induced and increased by AngII with the increase of concentrations and action times compared with that in the control group.The expression of Fas was increased and Bcl-2 was decreased with the increase of the concentrations and action times of AngII in fosinopril group compared with that in the AngII group.CONCLUSION: The apoptosis rate and the expression of apoptosis genes are induced and increased by angiotensin II with the increase of the concentrations and the action times.Fosinopril has the regulation effect on the apoptosis rate and the expression of apoptosis genes in vascular smooth muscle cells.

Key words: angiotensin II, vascular smooth muscle, cell apoptosis and apoptosis gene, fosinopril

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