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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (4): 372-376.

• 综述与讲座 • 上一篇    下一篇

细胞凋亡抑制蛋白( IAPs)与肿瘤治疗的策略

马静, 袁守军   

  1. 军事医学科学院放射医学研究所药理毒理研究室, 北京 100850
  • 收稿日期:2002-05-17 修回日期:2002-06-05 出版日期:2002-08-26 发布日期:2020-11-24
  • 通讯作者: 袁守军, 男, 药学博士后, 副研究员, 硕士生导师, 主要从事肿瘤药理和药物安全评价研究工作。Tel:010-66930271 E-mai l:yuansj@nic.bmi.ac. cn
  • 作者简介:马静, 女, 硕士研究生。

Inhibitor of apoptosis protein and strategy of tumor therapy

MA Jing, YUAN Shou-Jun   

  1. Department of Pharmacology and Toxicology, Institute of Radiation, Academy of Military Medical Sciences, Beijing 100850
  • Received:2002-05-17 Revised:2002-06-05 Online:2002-08-26 Published:2020-11-24

摘要: 凋亡是维持机体稳定的重要过程, 其功能失调与多种疾病的发生有关。IAPs 家族蛋白参与凋亡的调节, 与肿瘤的关系受到人们的关注。本文对近年来IAPs 家族蛋白和以其某些成员为靶点的抗癌策略的研究进展作一概述。

关键词: 细胞凋亡抑制蛋白, 治疗, 肿瘤

Abstract: Apoptosis is a cell suicide process with a major role in development and homeostasis in bodies. Dysregulation of apoptosis, involved with inhibitors of apoptosis ( IAPs), contributes a variety of disease states including cancer. The recent progress of members of IAPs family and the anticancer strategy against IAPs is reviewed in this paper.

Key words: inhibitor of apoptosis protein, therapy, tumor

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