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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (2): 146-148.

• 研究原著 • 上一篇    下一篇

甘糖酯对豚鼠乳头状肌动作电位和收缩的抑制作用

段东晓, 朱红灿1, 汤树本, 姚运纬   

  1. 郑州大学医学院生理学教研室, 郑州 450052 河南;
    1华中科技大学同济医学院, 武汉 430030, 湖北
  • 收稿日期:2002-11-04 修回日期:2002-11-25 出版日期:2003-04-26 发布日期:2020-11-25
  • 通讯作者: 段东晓, 女, 讲师, 硕士,从事心血管生理学研究。Tel:0371-6973648 E-mail:duandongxiao67@sina
  • 作者简介:汤树本, 男, 教授, 硕士生导师, 从事心血管生理学研究。

Inhibitory actions of propylene glycol mannate sulfate on action potentials and contraction of papillary muscles in guinea pigs

DUAN Dong-Xiao, ZHU Hong-Can1, TANG Shu-Ben, YAO Yun-Wei   

  1. Department of Physiology, Medical College of ZhengzhouUniversity, Zhengzhou, 450052, Henan;
    1Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei
  • Received:2002-11-04 Revised:2002-11-25 Online:2003-04-26 Published:2020-11-25

摘要: 目的: 观察甘糖酯(PGMS)对豚鼠乳头状肌动作电位和收缩力的影响。方法: 利用细胞内微电极技术记录豚鼠乳头状肌的快反应动作电位、慢反应动作电位及收缩力。结果: PGMS 浓度依赖性地使FAP 的动作电位时程缩短和FC 减弱, 但对静息电位和动作电位幅度及0 期最大除极速率均无显著影响。PGMS 浓度依赖性地使BaCl2 诱发的SAP 的Vmax 和APA 降低,APD 缩短。PGMS 浓度依赖性的使异丙肾上腺素诱发的SAP 的APA 降低,APD 缩短,FC 减弱。提高细胞外Ca2 +浓度后, 以上各项参数基本恢复正常。结论: PGMS 对乳头状肌动作电位和收缩力的影响可能是选择性抑制慢内向电流。

关键词: 药理学, 多糖, 乳头状肌, 动作电位, 钙通道, 心肌收缩, 钡化合物, 异丙肾上腺素

Abstract: AIM: To examine the effects of propylene glycol mannate sulfate (PGMS)on the action potentials and contractile force in guinea pig papillary muscles. METHODS: An intracellular microelectrode was used to record fast (FAP)and slow (SAP) action potentials. RESULTS: PGMS concentration-dependently decreased the contractile force and the action potential duration (APD) of FAP without affecting the resting potential (RP), action potential amplitude (APA), and maximal upstroke velocity (Vmax).The Vmax, APA, and APD of BaCl2-induced SAP were concentration-dependently decreased by PGMS and the effects were antagonized by isoprenaline.The APA and APD of isoprenaline-induced SAP were decreased by PGMS in a concentration-dependent manner and the effects were attenuated by elevation of intracellular Ca2+ concentration. CONCLUSLON: PGMS selectively inhibits the slow inward current.

Key words: pharmacology, polysaccharides, papillary muscles, action potentials, calcium channels, myocardial contraction, barium compounds, isoproterenol

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