欢迎访问《中国临床药理学与治疗学》杂志官方网站,今天是

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (1): 75-77.

• 研究原著 • 上一篇    下一篇

四种维生素组合对高脂喂养家兔心血管活性因子的影响1

谷兆侠, 李西兴, 周延升, 赵长安, 张煜, 王卫民2, 谷俊侠3   

  1. 新乡医学院生物化学教研室, 新乡 453003, 河南; 2新乡医学院第一附属医院, 卫辉 453100, 河南; 3江苏大学医学技术学院, 镇江 212001, 江苏
  • 收稿日期:2002-10-07 修回日期:2002-10-20 发布日期:2020-11-25
  • 通讯作者: 谷兆侠, 男, 硕士研究生, 副教授, 主要从事动脉粥样硬化及缺血性心脑血管疾病的研究。Tel:0373-3029423
  • 基金资助:
    1 河南省教育厅基金资助项目(№1999310014)

Effect of four vitamins in combination on cardiovascular activity elements in rabbits fed with high-lipids feed1

GU Zhao-Xia, LI Xi-Xing, ZHOU Yan-Sheng, ZHAO Chan-An, ZHANG Yu, WANG We-Min2, GU Jun-Xia3   

  1. Department of Biochemistry, Xinxiang Medical College, Xinxiang 453003, Henan; 2The First Affiliated Hospital Xinxiang Medical College, Weihui 453100, Henan; 3 School ofMedical Technology, Jiangsu University, Zhenjiang 212001, Jiangsu
  • Received:2002-10-07 Revised:2002-10-20 Published:2020-11-25

摘要: 目的: 探讨在动脉粥样硬化危险因子作用下,维生素对家兔多种血管活性物质的影响, 以了解维生素对动脉粥样硬化的发生是否有预防作用。方法: 26 只雄性家兔随机分成3 组。正常对照组喂饲普通饲料, 模型组和维生素处理组在普通饲料中加入胆固醇、猪油和甲硫氨酸。同时维生素组每天通过灌胃法给予维生素E、C、B6 和叶酸。分别于第4wk、第8 wk 未取血测相关指标和制备病理标本。结果: 与对照组相比, 模型组血浆内皮素和血栓素B2/6-酮-前列腺素F值明显升高, 而血清一氧化氮在两组间变化不明显。维生素组血浆内皮素和血栓素B2 比模型组明显下降, 而一氧化氮和6-酮-前列腺素F明显升高。与对照组比较, 模型组的病理变化显著, 用维生素处理后病变程度减轻。结论: 实验结果提示, 维生素E、C、B6 和叶酸的联合运用, 可以减轻或阻断动脉粥样硬化危险因子对血管内皮的损伤, 纠正血管活性物质分泌失衡, 对预防动脉粥样硬化的发生有益。

关键词: 药效学, 维生素, 动脉粥样硬化, 血管内皮

Abstract: AIM: To study the effects of vitamins on vascular activity elements in rabbits with atherosclerosis risk factors to determine whether vitamins have a role in preventing atherosclerosis.METHODS: 26male Chinese rabbits were randomly divided into 3 groups.The first group was fed with normal feed as control group (n=6).The other two groups were fed with normal feed plus cholesterol, lard andmethionine as model group (n=10) and vitamin treatment group (n=10) respectively.In addition, the vitamin group was given multi-vitamin daily by gastrogavage.The experiment lasted for 8 wk.The vascular activity elements of the three groups were detected by radioimmunoassay and nitrate reductase respectively, and the aorta pathological sample was prepared.RESULTS: In model group, the levels of plasma endothelin and thromboxane B2 6-keto-prostaglandin Fwere significantly increased compared with control group, but serum nitric oxide showed no obvious changes between both groups.In vitamin group, the levels of plasma endothelin and thromboxane B2 were significantly decreased, and the levels of 6-keto-prostaglandin F1αand nitric oxide were significantly increased compared with model group.In model group, there were significant pathological lesions, but the lesion was decreased by vitamin treatment.CONCLUTION: The vitamins supplement can alleviate or block the impairment of vascular endothelia caused by atherosclerosis risk factors, and help adjust the equilibrium of vascular activity elements.Therefore vitamins may play a positive role in preventing atherosclerosis.

Key words: pharmacodynamics, vitamin, atherosclerosis, endothelium vascular, hyperlipoidemia, hyperhomocysteinemia

中图分类号: