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中国临床药理学与治疗学 ›› 2000, Vol. 5 ›› Issue (4): 327-329.

• 论著 • 上一篇    下一篇

福辛普利在心力衰竭治疗中的价值

蔡恒, 王凤芝, 张雪娥   

  1. 山西医科大学第二医院, 太原030001
  • 收稿日期:2000-05-19 修回日期:2000-10-13 出版日期:2000-12-26 发布日期:2020-11-27
  • 作者简介:蔡恒,男,29岁,现山东医科大学博士生。

Therapeutic value of fosinopril in heart failure

CAI Heng, WANG Feng-Zhi, ZHANG Xue-E   

  1. Second Affiliated Hospital, Shanxi Medical University, Taiyuan 030001
  • Received:2000-05-19 Revised:2000-10-13 Online:2000-12-26 Published:2020-11-27

摘要: 目的 观察福辛普利在心力衰竭治疗中的价值。方法 30 只SD 大鼠随机分为3组:空白对照组、心衰组和福辛普利组。经处理14wk后,测血液动力学指标、心肌细胞凋亡率、左心室质量指数、心肌间质纤维化程度等。结果 心衰组各项血液动力学指标较对照组明显恶化,而用福辛普利治疗后明显改善(P<0.01);且左室质量指数亦较对照组明显增加(P<0.01),福辛普利治疗后明显减轻(P<0.01),与对照组比较无明显差异(P>0.05);细胞凋亡率以心衰组最大,福辛普利治疗后明显减小(P<0.01)。结论 福辛普利可降低心肌细胞凋亡率,提示其有心肌保护作用,可改善心衰的预后。

关键词: 福辛普利, 心力衰竭

Abstract: Aim To investigate the therapeutic value of fosinopril in heart failure.Methods Thirty SD rats were divided into three groups at random.Rats in heart failure group and fosinopril group were given an 8 weeks overswimming exercise to induce heart failure and the heart failure rats in fosinogril group were treated with fosinopril orally (2 mg·kg·d-1)for 6 weeks.14 weeks late r the hemodynamic indexes, myocardiac apoptosis rate, left ventricular mass index (LVM I)and myocardiac interstitial fibrosis were determined.Results The hemodynamic indexes in heart group were remarkably different from those in normal control group, while there was a significant improvement in fosinopril group (P<0.01).Left ventricular mass index in heart failure group was more increased than in the control(P<0.01), but it was significantly decreased in fosinopril group (P<0.01).Myocardiac apoptosis rats was highest in heart failure group, and it was decreased when treated with fosinopril(P<0.01).Conclusion Fosinopril could drop the myocardiac apoptosis rats.It suggests that fosinopril has protecting myocardium effect, andim proves prognosis of patients with heart failure.

Key words: fosinopril, heart failure

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