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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 231-233.

• 临床研究 • 上一篇    下一篇

骨化三醇对腹透患者钙磷代谢及T淋巴细胞亚群的影响

蔡楚丹, 蔡聪, 卢娟娟, 卓乐莹, 钟卓衡, 周佩芳   

  1. 汕头大学医学院第一附属医院肾脏内科, 汕头 515041
  • 收稿日期:2002-02-19 修回日期:2002-03-13 发布日期:2020-12-01

Influence of calcitriol on calcium phosphorus metabolism and Tlympho-cyte subpopulation in peritoneal dialysis patients

CAI Chu-Dan, CAI Cong, LU Juan-Juan, ZHUO Yu-Yin, ZHENG Zhuo-Heng, ZHOU Pei-Fang   

  1. Department of Nephrology, the First Affiliated Hospital, Medical College of Shantou University, Shantou 515041
  • Received:2002-02-19 Revised:2002-03-13 Published:2020-12-01

摘要: 目的: 了解骨化三醇(1, 25-(OH) 2D3, 罗钙全) 对腹膜透析患者钙磷代谢及免疫功能的影晌。方法: 观察37 例腹膜透析(PD) 患者服用骨化三醇前后血清T 细胞亚群、IL-8 以及血免疫反应甲状旁腺激素(iPTH) 、钙、磷水平变化。结果: 用药前 PD组血清T 淋巴亚群的 CD4/CD8 低于正常对照组(P<0.05), 服用骨化三醇 4 wk 后, CD4/CD8 从 0.56±0.10升至0.79±0.12;而 iPTH 显著降低, 血钙显著升高, 血磷明显下降。结论: 骨化三醇能改善PD患者钙磷代谢, 进而改善其免疫功能。

关键词: 腹膜透析, T 细胞亚群, IL-8, 骨化三醇

Abstract: AIM: To observe the influence of cal-citriol (1, 25-(OH) 2D3) on calcium phosphorus metabolism andimmunologic function of peritoneal dialy-sis (PD) patients.METHODS: The level of serum T cell subpopulation, IL-8, immunoreactive parathyroid hormone(iPTH), calcium, and phosphorus were observed before and after patients taking calcitriol.RESULTS: Before taking medicine, CD4/CD8 of group PD was lower than that of normal comparing group (P<0.05);4 weeks after taking calcitriol, CD4/CD8 rised from 0.56±0.10 to 0.79±0.12, andiPTH clearly reduces, while blood calcium, and blood phosphorus obviously goes down as well.CONCLUSION: Calcitriol is able to improve the calcium phosphorus metabolism of PD patients, and their immunologic function.

Key words: peritoneal dialysis, Tlymphocyte sub-groups, interleukin-2, calcitriol

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