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中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (2): 101-103.

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抗病毒新药17997 抗病毒效应的细胞微量量热的研究

鲁建华, 谭安民1, 陶佩珍2   

  1. 兰州医学院第二附属医院, 兰州730030
    1北京医科大学天然药物及仿生药物国家重点实验室;
    2中国医科院医药生物技术研究所病毒室
  • 收稿日期:1999-01-25 修回日期:1999-02-23 出版日期:1999-06-26 发布日期:2020-12-04
  • 作者简介:鲁建华,男,硕士,副主任医师。谭安民,男,博士后,从事药物化学研究。陶佩珍,中国医科院医药生物技术研究所病毒室主任,博士生导师。

Microcalorimetric study of ant iviral effect of antiviral antibiotic 17997

LU Jian-Hua, TAN An-Min, TAO Pei-Zhen   

  1. The Secnod Affiliated Hospital of Lanzhou Medical College, 730030
  • Received:1999-01-25 Revised:1999-02-23 Online:1999-06-26 Published:2020-12-04

摘要: 目的 研究抗病毒新药17997 对细胞代谢的影响和抑制病毒复制时细胞热效应的变化。方法 利用微量量热的方法。结果 热代谢曲线表明, 在有效抑制病毒复制浓度下, 17997不影响宿主细胞的正常代谢, 且能明显地降低病毒复制时的细胞热代谢。结论 17997 能够抑制病毒复制, 对宿主细胞的热代谢没有影响。

关键词: 微量量热法, 单纯疱疹病毒Ⅰ型, 抗生素17997

Abstract: Aim and Methods The thermog enesis curves of Vero cells infected by HSV-Ⅰ and the effect of 17997, a newly-found antiviral antibiotic, on the duplication of HSV-Ⅰ were determined by the LKB 2277 themal activity monitor.Results We found that HSV-Ⅰ interfered a with the metabolism of the Vero cells that had been infected and there was an increase in the heat production.When the Vero cells were treated with 17997 at the concent ration of 1×10-6mol·ml-1, the thermo genesis curves can decline to that of normal metabolism of Vero cells. Conclusion The antibiot ic 17997 can inhibit the duplication of HSV-Ⅰ and has no effect on the metabolism of Vero cells.

Key words: microcalorimet ry, HSV-Ⅰ, antibiotic 17997

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