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中国临床药理学与治疗学 ›› 1998, Vol. 3 ›› Issue (1): 26-29.

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伊那普利治疗糖尿病肾病的临床研究

余宗梅, 王文刚, 李庆德1   

  1. 徐州财贸职工医院, 徐州221005;
    1徐州医学院
  • 收稿日期:1997-10-16 修回日期:1997-12-03 出版日期:1998-03-26 发布日期:2020-12-04
  • 作者简介:余宗梅, 女, 32 岁, 药剂师。李庆德, 男, 41 岁, 副教授, 研究方向:糖尿病并发症的防治。

Curative effect of enalapril on diabetic nephropathy

YU Zhong-Mei, WANG Wen-Gang, LI Qing-De1   

  1. Xuzhou Commerce Workers' Hospital, Xuzhou, 221005;
    1Xuzhou Medical College
  • Received:1997-10-16 Revised:1997-12-03 Online:1998-03-26 Published:2020-12-04

摘要: 目的 评估伊那普利治疗糖尿病肾病(DN)的临床疗效, 并探讨其作用机制。方法 40 例持续微量蛋白尿的非胰岛素依赖型糖尿病(NIDDM)患者随机分为常规治疗组(n=19)和伊那普利治疗组(n=21)。利用131I-邻碘马尿酸钠测定有效肾血浆流量(ERPF);肾小球滤过率(GFR)以内生肌酐清除率表示;通过ELISA 法测定尿微量蛋白, 包括白蛋白(ALB)、转铁蛋白(TF)、视黄醇结合蛋白(RBP)和N-乙酰-β 氨基葡萄糖苷酶(NAG)。结果 伊那普利治疗组增高的尿ALB、TF、RBP 和NAG 均显著下降;ERPF 显著增加;增加的滤过分数(FF)显著减低。而常规治疗组这些参数无显著变化。结论 伊那普利具有改善DN 患者的肾小球血流动力学, 保护肾小球和肾小管功能的作用。

关键词: 糖尿病肾病, 血管紧张素转换酶抑制剂, 肾功能

Abstract: Aim Clinical effects and mechanisms of enalapril on diabetic nephropathy were investigated. Methods Forty cases of non-insulin-d ependent diabetes mellitus normotension with microalbuminuria were randomly div ided into two groups:routine group and enalapril group.The following parameters were measured:effective renal plasma flow (ERPF)assesed by131I-O-sodium iodohippurate(131I-OIH)clearance rate;g lomerular filtration rate (GFR)assessed by crea rance;urinary microprotein excretion, including albumin, transferrin, retinol binding protein (RBP)and N-acetyl-β-D-gluco saminide (NAG)by E LISA method, before and after receiving enalapril for 8 w eeks.Results In the enalpril group the elevated urinary albumin, T F, RBP, and NAG were ma rkedly decreased (P<0.05).ERPF was signif icant ly increased (P<0.01) and the eleveted filtration fraction(FF)was significantly reduced(P<0.01). These paramete rs had no signif icant change throughout the study in the routine group.Conclusion Enalapril might improve the renal hemodynamic and prese rverenal function in diabetic nephropathy.

Key words: diabetic nephropathy, angiotensin converting enzyme ingibitor, renal function

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