硫酸吲哚酚在慢性肾病并发症中的作用

doi:10.12092/j.issn.1009-2501.2022.06.011

中国临床药理学与治疗学 ›› 2022, Vol. 27 ›› Issue (6): 672-679.doi: 10.12092/j.issn.1009-2501.2022.06.011

硫酸吲哚酚在慢性肾病并发症中的作用

朱新如1,2，黄鑫1,2,3

1中国药科大学药物科学研究院新药筛选中心，南京 210009，江苏；2江苏省药效研究与评价服务中心，南京 210009，江苏；3中国药科大学药物质量与安全预警教育部重点实验室，南京 210009，江苏

收稿日期:2022-04-14 修回日期:2022-05-20 出版日期:2022-06-26 发布日期:2022-07-08
通讯作者: 黄鑫，女，博士，副研究员，硕士生导师，主要从事药物分析研究。 E-mail: huangxin@cpu.edu.cn
作者简介:朱新如，女，硕士研究生，主要从事体内药物分析研究。 E-mail: 1483455695@qq.com
基金资助:
国家自然科学基金（82174072）

Roles of indoxyl sulfate in complications of chronic kidney disease

ZHU Xinru1,2, HUANG Xin1,2,3

1New Drug Screening Center, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 2Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; 3Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2022-04-14 Revised:2022-05-20 Online:2022-06-26 Published:2022-07-08

摘要/Abstract

摘要： 慢性肾病（chronic kidney disease, CKD）是全球性公共卫生问题，其发生发展与体内尿毒症毒素暴露密切相关。硫酸吲哚酚（indoxyl sulfate, IS）是一种肠源性的蛋白结合型尿毒症毒素，由于CKD患者肾脏排泄功能被破坏，IS在CKD患者体内蓄积。IS不仅促进CKD进展，还诱导其他组织器官病变，进而引起CKD相关的并发症。本文综述了IS对CKD患者血管、肌肉、骨骼以及大脑的影响及其相应的机制，并总结通过清除IS治疗CKD的方法。

关键词: 慢性肾病, 尿毒症毒素, 慢性肾病并发症, 硫酸吲哚酚

Abstract: Chronic kidney disease is a global public health problem, and its occurrence and development are closely related to the exposure of uremic toxins in vivo. Indoxyl sulfate is one of protein-bound enterogenous uremic toxin, it significantly accumulates in patients with chronic kidney disease as renal function declines. Indoxyl sulfate not only promotes the progression of chronic kidney disease, but also induces pathological changes in other tissues and organs, causing complications in other organs related to chronic kidney disease. This article mainly reviews the effect of indoxyl sulfate on blood vessels, muscle, skeleton and brain and their mechanisms, and summarizes chronic kidney disease treatment by clearing indoxyl sulfate.

Key words: chronic kidney disease, uremic toxin, complications of chronic kidney disease, indoxyl sulfate

中图分类号:

R692

朱新如, 黄鑫. 硫酸吲哚酚在慢性肾病并发症中的作用[J]. 中国临床药理学与治疗学, 2022, 27(6): 672-679.

ZHU Xinru, HUANG Xin. Roles of indoxyl sulfate in complications of chronic kidney disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 672-679.

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硫酸吲哚酚在慢性肾病并发症中的作用

Roles of indoxyl sulfate in complications of chronic kidney disease

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