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中国临床药理学与治疗学 ›› 2022, Vol. 27 ›› Issue (11): 1307-1314.doi: 10.12092/j.issn.1009-2501.2022.11.014

• 综述与讲座 • 上一篇    下一篇

调理肠道菌群:治疗痛风的一种新策略

陈宇1,顾兵1,李华南2   

  1. 1江西科技师范大学药学院,南昌 330013,江西;2江西中医药大学附属医院骨伤三科,南昌 330006,江西
  • 收稿日期:2022-10-18 修回日期:2022-11-12 出版日期:2022-11-26 发布日期:2022-12-12
  • 通讯作者: 顾兵,男,博士,教授,研究方向:基础药理学。 E-mail: bguemory@hotmail.com
  • 作者简介:陈宇,女,在读硕士生,研究方向:免疫药理学。 E-mail: 1454700887@qq.com
  • 基金资助:
    国家自然科学基金资助项目(81860857;82060871);江西省自然科学基金项目(20202BAB206071);江西省教育厅科学技术研究项目(GJJ190582);江西省中医药管理局科技计划项目(2022Z001);江西省中医药管理局重点研究室、临床研究基地(第三批)(赣中医药科教函〔2022〕4号);2022年度江西中医药大学校级研究生创新专项资金立项资助项目(校字[2022]29号)(JZYC22S25)

Modulating gut miocrobiota: a new strategy in the treatment of gout  

CHEN Yu1, GU Bing1, LI Huanan2   

  1. 1College of Life Sciences, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi, China; 2Department of Traumatic Orthopedics, the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi, China

  • Received:2022-10-18 Revised:2022-11-12 Online:2022-11-26 Published:2022-12-12

摘要: 痛风是因嘌呤及尿酸代谢紊乱引起血尿酸持续性升高,致单钠尿酸盐晶体沉积诱发炎症反复发作性疾病,主要表现为尿酸升高和炎症发作。研究表明痛风与肠道菌群的改变互为因果,肠道菌群不仅能够影响嘌呤及尿酸代谢也可调节炎症反应。因此,调理肠道菌群有望成为治疗痛风的一种新策略。该文从肠道菌群调节嘌呤及尿酸代谢和炎症反应出发,以阐明调理肠道菌群作为痛风治疗新策略的具体应用方式。

关键词: 痛风, 肠道菌群, 尿酸代谢, 炎症反应

Abstract: Gout is a persistent increase in blood uric acid caused by purine and uric acid metabolism disorders, resulting in monosodium urate crystal deposition induced by recurrent inflammatory diseases, mainly manifested as elevated uric acid and inflammatory attacks. Studies have shown that gout and changes in the gut miocrobiota are mutually causal, and the gut miocrobiota can not only affect purine and uric acid metabolism but also regulate inflammatory response. Therefore, regulating the gut miocrobiota is expected to become a new strategy for the treatment of gout. This article starts from the regulation of purine and uric acid metabolism and inflammatory response by gut miocrobiota, so as to clarify the specific application of gut miocrobiota regulation as a new strategy for gout treatment.

Key words: gout, gut miocrobiota, uric acid metabolism, inflammation response

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