诱导痰检测在慢性气道病中的应用及发展前景

doi:10.12092/j.issn.1009-2501.2024.04.002

中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (4): 370-376.doi: 10.12092/j.issn.1009-2501.2024.04.002

• 慢性气道疾病药物治疗新进展 • 上一篇下一篇

诱导痰检测在慢性气道病中的应用及发展前景

高佳萌1,2，沈瑶2，薛丽萍1，陈智鸿1

1复旦大学附属中山医院呼吸与危重医学科，上海 200032；2上海市浦东医院，复旦大学附属浦东医院，呼吸与危重症医学科，上海 201399

收稿日期:2023-09-28 修回日期:2023-11-05 出版日期:2024-04-26 发布日期:2024-03-25
通讯作者: 陈智鸿，女，博士，教授，主任医师，主要从事气道炎症疾病的基础与临床研究。 E-mail： chen.zhihong@zs-hospital.sh.cn
作者简介:高佳萌，女，在读硕士，主要从事呼吸科疾病的基础与临床研究。 E-mail： gaojiameng2000@163.com
基金资助:
国家自然科学基金（81970023，82270026）

Induced sputum testing in chronic airway disease and the prospects for its development

GAO Jiameng1.2, SHEN Yao2, XUE Liping1, CHEN Zhihong1

1Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China; 2Department of Pulmonary and Critical Care Medicine, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China

Received:2023-09-28 Revised:2023-11-05 Online:2024-04-26 Published:2024-03-25

摘要/Abstract

摘要：

诱导痰检测是一种可反映气道炎症性质及程度的非侵袭性检测手段，在慢性气道疾病中的诊断、治疗和预后中均发挥了重要作用。本文概述了诱导痰技术的发展历史，介绍了诱导痰技术的原理与操作方法，评估了其安全性，归纳了三大主要检测内容，详实地阐述了该技术在各慢性气道疾病中的作用，如反映气道炎症类型、预测药物疗效及与转录组学结合进行疾病机制研究等，并简要梳理了其创新性，做出未来愿景。

关键词: 诱导痰技术, 慢性气道病, 应用进展, 发展前景

Abstract:

Induced sputum testing is a non-invasive test that reflects the nature and extent of airway inflammation and plays an important role in the diagnosis, treatment and prognosis of chronic airway diseases. This article outlines the development history of induced sputum technology, introduces the principle and operation of induced sputum technology, evaluates its safety, summarizes the three main test components, elaborates the role of this technology in various chronic airway diseases, such as reflecting the type of airway inflammation, predicting the efficacy of medication, and combining it with transcriptomics to study disease mechanisms, and briefly summarizes its innovations and makes a vision for the future.

Key words: induced sputum technique, chronic airway disease, application progress, prospects for development

中图分类号:

R825.6

高佳萌, 沈瑶, 薛丽萍, 陈智鸿. 诱导痰检测在慢性气道病中的应用及发展前景[J]. 中国临床药理学与治疗学, 2024, 29(4): 370-376.

GAO Jiameng, SHEN Yao, XUE Liping, CHEN Zhihong. Induced sputum testing in chronic airway disease and the prospects for its development[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2024, 29(4): 370-376.

诱导痰检测在慢性气道病中的应用及发展前景

Induced sputum testing in chronic airway disease and the prospects for its development

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