双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估

doi:10.12092/j.issn.1009-2501.2026.08.009

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (8): 1085-1090.doi: 10.12092/j.issn.1009-2501.2026.08.009

• 药物治疗学 • 上一篇

双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估

刘婷婷¹^,²(), 胡梦雪¹^,², 刘亚如¹^,², 叶翀¹^,², 夏泉¹^,²^,*()

1. 安徽医科大学第一附属医院药剂科，国家中医药管理局中药化学三级实验室，合肥 230022，安徽
2. 安徽医科大学药学科学院，合肥 230032，安徽

收稿日期:2024-12-20 修回日期:2025-03-26 出版日期:2026-08-26 发布日期:2026-09-09
通讯作者: 夏泉 E-mail:908810474@qq.com;xiaquan2010@163.com
作者简介:刘婷婷，女，博士，副主任药师，硕士生导师，研究方向：临床药学、抗炎免疫药理学。E-mail：liutingting@ahmu.edu.cn
基金资助:
国家自然科学基金青年科学基金资助项目（81903622）；安徽省高等学校省级质量工程项目（2023jyxm0981）；安徽省教育厅高校优秀拔尖人才培育项目（gxgwfx2021016）；新安医学教育部重点实验室开放课题（2024xayx06）；安徽省高校自然科学研究项目（2023AH053290）；安徽省转化医学研究院科研基金项目（2022zhyx-C30）

Effect of bicyclol in abnormal liver function induced by chemotherapy in gynecologic tumors

Tingting LIU¹^,²(), Mengxue HU¹^,², Yaru LIU¹^,², Chong YE¹^,², Quan XIA¹^,²^,*()

1. Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei 230022, Anhui, China
2. School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, Anhui, China

Received:2024-12-20 Revised:2025-03-26 Online:2026-08-26 Published:2026-09-09
Contact: Quan XIA E-mail:908810474@qq.com;xiaquan2010@163.com

摘要/Abstract

摘要：

目的: 短期评估双环醇防治妇科肿瘤化疗所致肝功能指标异常的临床疗效。方法: 选取2020至2022年在本院行妇科肿瘤化疗引起肝功能指标异常的40例患者，分为双环醇组（观察组20例）和甘草酸组（对照组20例），双环醇组接受双环醇片保肝治疗，甘草酸组接受甘草酸口服制剂（甘草酸二铵肠溶胶囊或复方甘草酸苷片）保肝治疗。比较两组患者治疗前后肝功能指标变化，评价疗效，观察是否有不良反应发生。结果: 患者基线资料可比，化疗后两组患者谷丙转氨酶（ALT）、谷草转氨酶（AST）、谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）、总胆红素（TBIL）和直接胆红素（DBIL）升高，经保肝药治疗后两组患者上述指标有所降低，双环醇组对ALT的降低作用较甘草酸组更显著（P<0.05），其他指标两组间无统计学差异（P>0.05）；双环醇组临床治疗总有效率有高于甘草酸组的趋势，但未显示统计学差异（P>0.05）；两组均未观察到不良反应。结论: 甘草酸口服制剂和双环醇片均能缓解妇科肿瘤化疗所致肝功能指标异常，与甘草酸口服制剂相比，双环醇片降低肝酶效果更佳，该指标异常升高患者可优先选择双环醇片治疗。

关键词: 双环醇片, 甘草酸口服制剂, 妇科肿瘤化疗, 肝功能指标异常

Abstract:

AIM: To explore the effect of bicyclol in preventing and treating abnormal liver function indexs, which induced by chemotherapy in gynecologic tumors. METHODS: A total of 40 patients with abnormal liver function indices induced by chemotherapy for gynecologic tumors were selected from 2020 to 2022. They were divided into the bicyclol treatment group and the glycyrrhizin treatment (oral diammonium glycyrrhizinate enteric-coated capsules or compound glycyrrhizin tablets). Compared the changes in liver function indexs to evaluate the effect and adverse reaction between the two groups. RESULTS: After chemotherapy, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma- glutamyl transferase (GGT), alkaline phosphatase (ALP), total bilirubin (TBIL), and direct bilirubin (DBIL) elevated. Following hepatoprotective treatment, these indexs decreased in both groups. Bicyclol tables reduced ALT more significantly than glycyrrhizin group (P<0.05). There was not adverse reactions in either group. CONCLUSION: Oral glycyrrhizin and bicyclol tablets are both effective in alleviating abnormal liver function indices caused by chemotherapy in gynecologic tumors. Compared to oral glycyrrhizin, bicyclol tablets demonstrate a superior effect in reducing liver enzyme levels. Patients with significantly elevated liver enzyme levels should consider bicyclol tablets as the preferred treatment option.

Key words: bicyclol tablet, oral glycyrrhizin, gynecologic tumor chemotherapy, abnormal liver function index

中图分类号:

R737

刘婷婷, 胡梦雪, 刘亚如, 叶翀, 夏泉. 双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估[J]. 中国临床药理学与治疗学, 2026, 31(8): 1085-1090.

Tingting LIU, Mengxue HU, Yaru LIU, Chong YE, Quan XIA. Effect of bicyclol in abnormal liver function induced by chemotherapy in gynecologic tumors[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(8): 1085-1090.

图/表 7

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Groups	n	Age (years)	Weight (kg)	Course (years)
Dicyclol	20	54.20±10.59	59.55±10.70	1.50±1.74
Glycyrrhizin	20	49.35±8.96	61.99±12.37	1.40±1.64
t	-	1.5640	0.6672	0.1893
P	-	0.1262	0.5087	0.8509

Groups	n	Age (years)	Weight (kg)	Course (years)
Dicyclol	20	54.20±10.59	59.55±10.70	1.50±1.74
Glycyrrhizin	20	49.35±8.96	61.99±12.37	1.40±1.64
t	-	1.5640	0.6672	0.1893
P	-	0.1262	0.5087	0.8509

Groups	n	ALT (U/L)	AST (U/L)	GGT (U/L)	ALP (U/L)	TBIL (μmol/L)	DBIL (μmol/L)
Dicyclol	20	24.35±12.65	25.85±11.70	49.85±68.48	115.60±110.73	11.15±4.01	2.12±0.96
Glycyrrhizin	20	28.45±23.46	30.80±21.89	42.50±30.20	174.05±306.00	13.10±10.48	3.09±5.20
t	-	0.6879	0.8919	0.4392	0.8033	0.7772	0.8204
P	-	0.4957	0.3781	0.6630	0.4268	0.4419	0.4171

Groups	n	ALT (U/L)	AST (U/L)	GGT (U/L)	ALP (U/L)	TBIL (μmol/L)	DBIL (μmol/L)
Dicyclol	20	24.35±12.65	25.85±11.70	49.85±68.48	115.60±110.73	11.15±4.01	2.12±0.96
Glycyrrhizin	20	28.45±23.46	30.80±21.89	42.50±30.20	174.05±306.00	13.10±10.48	3.09±5.20
t	-	0.6879	0.8919	0.4392	0.8033	0.7772	0.8204
P	-	0.4957	0.3781	0.6630	0.4268	0.4419	0.4171

Groups	n	ALT (U/L)	AST (U/L)	GGT (U/L)	ALP (U/L)	TBIL (μmol/L)	DBIL (μmol/L)
Dicyclol	20	50.00±24.39	46.15±24.71	87.84±81.95	145.84±135.55	12.68±4.95	2.52±1.14
Glycyrrhizin	20	70.70±54.76	63.05±34.43	67.85±57.64	169.05±263.23	13.14±7.10	2.76±2.05
t	-	1.5440	1.7830	0.8923	0.3506	0.2377	0.4576
P	-	0.1308	0.0825	0.3779	0.7278	0.8134	0.6499

双环醇对妇科肿瘤化疗所致肝功能指标异常的短期评估

Effect of bicyclol in abnormal liver function induced by chemotherapy in gynecologic tumors

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Time	ALT (U/L)	AST (U/L)	GGT (U/L)	ALP (U/L)	TBIL (μmol/L)	DBIL (μmol/L)
Before chemotherapy	24.35±12.65	25.85±11.70	49.85±68.48	115.60±110.73	11.15±4.01	2.12±0.96
After chemotherapy	50.00±24.39^c	46.15±24.71^c	87.84±81.95	145.84±135.55	12.68±4.95	2.52±1.14
After treatment	28.15±18.83^f	32.50±15.91^e	66.00±65.59	117.35±123.79	13.08±5.33	2.36±1.10

Groups	n	Cured	Effective	Ineffective	Total effective	Total effective rate
Dicyclol	20	13	3	4	16	80.00%
Glycyrrhizin	20	8	5	7	13	65.00%
P	-	-	-	-	-	0.2881