腺苷受体调节睡眠觉醒作用机制进展

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (2): 214-218.

腺苷受体调节睡眠觉醒作用机制进展

余劼¹, 许奇², 王毅群¹

¹复旦大学上海医学院药理学系,
²医学神经生物学国家重点实验室,上海 200032

收稿日期:2011-01-14 修回日期:2011-02-08 发布日期:2011-04-20
通讯作者: 王毅群,女,讲师,研究方向:睡眠医学、神经激素药理学。Tel: 021-54237690 E-mail: 061101069@fudan.edu.cn
作者简介:余劼,男,临床医学八年制在读,研究方向:睡眠医学。Tel: 021-54237690 E-mail: 06301010167@fudan.edu.cn
基金资助:
“重大新药创制”科技重大专项(2009ZX09303-006);国家自然科学基金 (30625021, 30821002, 30970955, 30901797, 31070957, 8100569);上海市科学技术委员会 (09PJ1401800, 09JC1402500, 10XD1400400, 10ZR1402100, 10441901600);上海市重点学科建设项目(B119);教育部博士点基金资助项目 (20070246186) 及中央高校基本科研业务费专项资金资助项目

Progress in the roles of adenosine receptors in sleep-wake regulation

YU Jie¹, XU Qi², WANG Yi-qun¹

¹Department of Pharmacology,
²the State Key Labaratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 20032, China

Received:2011-01-14 Revised:2011-02-08 Published:2011-04-20

摘要/Abstract

摘要： 腺苷是ATP代谢产物,在脑内广泛存在。腺苷受体分为A₁、A_2A、A_2B和A₃四种受体(receptor, R)亚型。研究显示:内源性腺苷可能通过A₁R和A_2AR发挥睡眠调节作用。A₁R在中枢系统分布广泛,兴奋位于觉醒系统组胺能、基底前脑胆碱能神经上的A₁R,诱发睡眠;腺苷A_2AR相对集中分布于前脑区,兴奋A_2AR可引起强大的睡眠效应;A_2AR可能介导内源性前列腺素D₂的睡眠调节作用,是咖啡因促觉醒作用的主要靶点。A₁R和A_2AR在睡眠觉醒调节中的贡献,至今仍有很大争议,本文综述腺苷受体睡眠调节作用研究进展。

关键词: 神经生物学, 腺苷受体, 基底前脑, 前列腺素D₂, 睡眠

Abstract: Adenosine, the product of ATP, widely presented in the brain is proposed to be an endogenous sleep-promoting substance. Among 4 subtypes of adenosine receptor (R), A₁R, A_2AR, A_2BR and A₃R, it has been reported that both adenosine A₁R and A_2AR mediate the somnogenic effects of adenosine. Activation of A₁R in the arousal histaminergic posterior hypothalamus, cholinergic basal forebrain and so on promotes sleep. A_2AR is mainly localized in the caudate-putaman, nucleus accumbens, olfactory tubercles. Activation of A_2AR significantly promotes sleep. A_2AR mediates the somnogenic effects of prostaglandin D₂, and acts as the target of caffeine. However, the roles of A₁R and A_2AR in sleep-wake regulation are in debate. This review summarizes the progress in the roles of adenosine receptors in sleep-wake regulation.

Key words: Neurobiology, Adenosine receptor, Basal forebrain, Prostaglandin D₂, Sleep

中图分类号:

R749

余劼, 许奇, 王毅群. 腺苷受体调节睡眠觉醒作用机制进展[J]. 中国临床药理学与治疗学, 2011, 16(2): 214-218.

YU Jie, XU Qi, WANG Yi-qun. Progress in the roles of adenosine receptors in sleep-wake regulation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 214-218.

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