利钠肽系统在肾脏的研究进展

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (2): 226-231.

利钠肽系统在肾脏的研究进展

林璋¹, 洪华山²

¹福建医科大学协和临床医学院
²福建医科大学附属协和医院干部病房,福州 350001,福建

收稿日期:2010-11-18 修回日期:2011-01-15 发布日期:2011-04-20
通讯作者: 洪华山,男,教授、主任医师,博士生导师,研究方向:高血压与心力衰竭。Tel: 0591-83357896-8455 E-mail: honghuashan@hotmail.com
作者简介:林璋,男,在读研究生,研究方向:高血压。Tel: 0591-83357896-8475 E-mail: linzhang1530@163.com
基金资助:
闽都中小银行教育发展基金会基金资助项目

New advances of renal natriuretic peptide system

LIN Zhang¹, HONG Hua-shan²

¹Union Clinical College, Fujian Medical University;
²Cares Ward, Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian, China

Received:2010-11-18 Revised:2011-01-15 Published:2011-04-20

摘要/Abstract

摘要： 利钠肽(ANP、BNP和CNP)是心房、心室肌及血管内皮细胞产生和分泌的一类具有强烈利尿、利钠、扩血管及降低血压等作用的多肽激素,通过结合靶器官的利钠肽受体(NPR-A、NPR-B和NPR-C)在全身和局部均发挥重要的调节作用。肾脏作为利钠肽最重要的靶器官之一,研究发现肾脏存在三型利钠肽及其受体的mRNA和蛋白质的表达,并形成一个局部的肾脏利钠肽系统。本文对肾脏利钠肽系统的研究现状及其重要意义作一综述。

关键词: 利钠肽, 利钠肽受体, 定位, 高血压

Abstract: The natriuretic peptides (ANP, BNP and CNP) are a family of related hormones that are secreted by atrium, ventricle or vascular endothelial cells with poten natriuretic, diuretic, vasorelaxant and hypotensive activities. Through combining natriuretic peptide receptors (NPR-A, NPR-B and NPR-C) on target cells, the natriuretic peptides exert an important role in systemic and local homeostasis. As one of the primary target organs of natriuretic peptides, kidney is found to show local mRNA and protein expression of natriuretic peptides and their receptors, forming a local renal natriuretic peptide system. In this paper, major recent developments and their significance of renal natriuretic peptide system are reviewed.

Key words: Natriuretic peptide, Natriuretic peptide receptor, Localization, Hypertension

中图分类号:

林璋, 洪华山. 利钠肽系统在肾脏的研究进展[J]. 中国临床药理学与治疗学, 2011, 16(2): 226-231.

LIN Zhang, HONG Hua-shan. New advances of renal natriuretic peptide system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(2): 226-231.

参考文献

[1] 洪华山,卓辉琳,江琼,等. SD大鼠左心室利钠肽三型受体的表达[J]. 心血管康复医学杂志,2009, 18(6): 521-523.
[2] Potter LR, Abbey-Hosch S, Dickey DM, et al. Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions[J].Endocr Rev,2006,27(1):47-72.
[3] Rose RA, Giles WR. Natriuretic peptide C receptor signalling in the heart and vasculature[J].J Physiol,2008,586(2):353-366.
[4] Totsune K, Takahashi K, Murakami O, et al. Natriuretic peptides in the human kidney[J].Hypertension,1994,24(6):758-762.
[5] Lai FJ, Hsieh MC, Hsin SC, et al. The cellular localization of increased atrial natriuretic peptide mRNA and immunoreactivity in diabetic rat kidneys[J].J Histochem Cytochem,2002,50(11):1501-150
[6] Terada Y, Tomita K, Nonoguchi H, et al. PCR localization of C-type natriuretic peptide and B-type receptor mRNAs in rat nephron segments[J].Am J Physiol,1994,267(2 Pt 2):215-222.
[7] Lai KN, Leung JC, Yandle TG, et al. Gene expression and synthesis of natriuretic peptides by cultured human glomerular cells[J].J Hypertens,1999,17(4):575-583.
[8] Lewko B, Endlich N, Kriz W, et al. C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stress[J].Kidney Int,2004,66(3):1001-1008.
[9] Martin ER, Lewicki JA, Scarborough RM, et al. Expression and regulation of ANP receptor subtypes in rat renal glomeruli and papillae[J].Am J Physiol,1989,257(4 Pt 2): 649-657.
[10]Ritter D, Dean AD, Gluck SL, et al. Natriuretic peptide receptors A and B have different cellular distributions in rat kidney[J].Kidney Int,1995,48(6):5758-5766.
[11]Bonhomme MC, Grove KL, Caron S, et al. Immunolocalization of natriuretic peptide receptor B in the rat kidney[J].J Am Soc Nephrol,1998,9(10):1777-1786.
[12]Lohe A, Yeh I, Hyver T, et al. Natriuretic peptide B receptor and C-type natriuretic peptide in the rat kidney[J].J Am Soc Nephrol,1995,6(6):1552-1558.
[13]Dean AD, Vehaskari VM, Ritter D, et al. Distribution and regulation of guanylyl cyclase type B in the rat nephron[J].Am J Physiol,1996,270(2 Pt 2):311-318.
[14]Nagase M, Katafuchi T, Hirose S, et al. Tissue distribution and localization of natriuretic peptide receptor subtypes in stroke-prone spontaneously hypertensive rats[J].J Hypertens,1997,15(11):1235-124
[15]Nagase M, Ando K, Katafuchi T, et al. Role of natriuretic peptide receptor type C in Dahl salt-sensitive hypertensive rats[J]. Hypertension,1997,30(2 Pt 1):177-183.
[16]Garland CJ, Dora KA. Evidence against C-type natriuretic peptide as an arterial ‘EDHF’[J]. Br J Pharmacol,2008,153(1):4-5.
[17]Endlich K, Steinhausen M. Natriuretic peptide receptors mediate different responses in rat renal microvessels[J].Kidney Int,1997,52(1):202-207.
[18]Shi SJ, Nguyen HT, Sharma GD, et al. Genetic disruption of atrial natriuretic peptide receptor-A alters renin and angiotensin II levels[J].Am J Physiol Renal Physiol,2001,281(4):665-673.
[19]Vaz Perez A, Doehner W, von Haehling S, et al. The relationship between tumor necrosis factor-alpha, brain natriuretic peptide and atrial natriuretic peptide in patients with chronic heart failure[J].Int J Cardiol,2010,141(1):39-43.
[20]Vellaichamy E, Zhao D, Somanna N, et al. Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy[J]. Physiol Genomics,2007,31(2):193-202.
[21]胡榕,洪华山,许昌声,等. 核因子-κB在凝血酶促自发性高血压大鼠血管平滑肌细胞增殖中的作用[J]. 中国临床药理学与治疗学,2008,13(6): 627-633.
[22]Woodard GE, Li X, Rosado JA. Water deprivation enhances the inhibitory effect of natriuretic peptides on cAMP synthesis in rat renal glomeruli[J].Am J Physiol Renal Physiol,2004,287(3):418-426.
[23]Costa MA, Elesgaray R, Caniffi C, et al. Role of nitric oxide as a key mediator on cardiovascular actions of atrial natriuretic peptide in spontaneously hypertensive rats[J].Am J Physiol Heart Circ Physiol,2010,298(3):778-786.
[24]Elesgaray R, Caniffi C, Ierace DR, et al. Signaling cascade that mediates endothelial nitric oxide synthase activation induced by atrial natriuretic peptide[J].Regul Pept,2008,151(1/2/3):130-134.