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中国临床药理学与治疗学 ›› 2022, Vol. 27 ›› Issue (4): 433-441.doi: 10.12092/j.issn.1009-2501.2022.04.013

• 心血管疾病药物治疗最新研究进展 • 上一篇    下一篇

高血压药物治疗与非药物治疗研究进展

徐建飞,林利   

  1. 1同济大学医学院,上海 200092;2同济大学附属东方医院心血管内科,上海 200120
  • 出版日期:2022-04-26 发布日期:2022-05-17
  • 通讯作者: 林利,女,主任医师,博士研究生导师,研究方向:高血压和心衰的机制研究。 E-mail: linli777@126.com
  • 作者简介:徐建飞,男,博士研究生,研究方向:高血压的机制研究。 E-mail: xjf902371@163.com
  • 基金资助:
    国家自然科学基金(81570237;81870197);上海市浦东临床顶级学科项目(PWYgf2021-01)

Research progress in pharmacological and non-pharmacological treatments of hypertension

XU Jianfei1, LIN Li2   

  1. 1Tongji University School of Medicine, Shanghai 200092, China; 2Department of Cardiovascular Medicine, Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China
  • Online:2022-04-26 Published:2022-05-17

摘要:

高血压是全世界最常见的慢性非传染性疾病,也是诱发心脑血管疾病最重要的危险因素。目前高血压治疗达标控制率不足50%,在很大程度上仍然未被有效的治疗管理。尽管在过去的四十年中进行了大量的临床研究和试验,但新型抗高血压药物的研究进展并不尽如人意。本综述讨论了近年来高血压患者药物治疗和非药物治疗方面的进展,并可能在未来为临床高血压治疗提供新方案。

关键词: 高血压, 药物治疗, 脑啡肽酶抑制剂, GLP-1

Abstract:

Hypertension is the most common chronic non-communicable disease in the world and the most important risk factor for cardiovascular and cerebrovascular diseases. At present, the control rate of hypertension treatment standard is less than 50%, and it is still not effectively managed to a large extent. Despite numerous clinical studies and trials over the past four decades, the progress of new antihypertensive drugs has not been satisfactory. This review discusses recent advances in pharmacological and non-pharmacological treatments for patients with hypertension, and may provide new options for clinical hypertension treatment in the future.

Key words: hypertension, pharmacological treatment, enkephalinase inhibitor, GLP-1

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