奥氮平治疗老年精神分裂症患者的疗效观察及对心电图的影响

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (3): 304-308.

奥氮平治疗老年精神分裂症患者的疗效观察及对心电图的影响

袁国锋¹, 俞玉礼²

¹杭州市公安局安康医院精神二科三病区,杭州 311113,浙江;
²杭州市余杭区仓前镇社区卫生服务中心药剂科,杭州 311000,浙江

收稿日期:2011-03-14 修回日期:2011-03-25 出版日期:2011-03-26 发布日期:2011-05-18
作者简介:袁国锋,男,副主任医师,研究方向:精神药理学。Tel: 13857153630 E-mail: yuanguofeng123@163.com

Efficacy and electrocardiogram abnormality of olanzapine in the treatment of old schizophrenic patients

YUAN Guo-feng¹, YU Yu-li²

¹Second Psychiatric Department, An Kang Hospital of Hangzhou Security Bureau, Hangzhou 311113 ,Zhejiang, China;
²Pharmaceutical Preparation Section, Community Center of Cang Qian Town, Yuhang District, Hangzhou 311000, Zhejiang , China

Received:2011-03-14 Revised:2011-03-25 Online:2011-03-26 Published:2011-05-18

摘要/Abstract

摘要： 目的: 比较奥氮平与利培酮治疗老年精神分裂症患者的疗效及对心电图的影响。方法: 选取120例老年精神分裂症患者,随机分为奥氮平组(研究组)和利培酮组(对照组),各60例,分别于治疗前及治疗后第2、4、6、8周末采用阳性与阴性症状量表(PANSS) 评定疗效,并进行心电图检查,统计异常心电图的数目和相关信息。结果: 两组PANSS评分治疗后均较治疗前明显下降(P<0.05)。研究组有效率和显效率分别为78.3%和 56.7%, 对照组分别为 75.0%和 51.7%, 差异无统计学意义(P>0.05)。奥氮平组以嗜睡为主,利培酮组以锥体外系副反应和转氨酶升高为主,两组在锥体外系副反应和转氨酶升高两方面有统计学差异(P<0.05)。治疗第2周时,心电图异常数奥氮平组较利培酮组少,差异有统计学意义(P<0.05)。结论: 奥氮平和利培酮对治疗老年精神分裂症的疗效相近,安全性较高,尤其是奥氮平的副作用更少,并且两种药物对心电图无明显影响,较适用于老年精神障碍患者。

关键词: 奥氮平, 利培酮, 老年, 精神分裂症, PANSS, 心电图

Abstract: AIM: To explore the efficacy and the electrocardiogram abnormality of olanzapine or risperidon in the treatment of old schizophrenic patients.METHODS: 120 patients with old schizophrenia were randomly divided into olanzapine group (60 cases) and risperidon group(60 cases) treated for 8 weeks. The efficacy was measured with the positive and negative symptoms scale (PANSS) and PANSS and the electrocardiogram test was used to evaluate the efficacy and adverse effects respectively before and at the ends of 2,4,6,8 weeks of treatment. The amount and information of electrocardiogram abnormality were analyzed.RESULTS: The efficacy rate of olanzapine was 78.3%,in which 56.7% was improved markedly. The efficacy rate of risperidon was 75.0%, in which 51.7% were improved markedly. There were no difference between two groups(P>0.05). There were significant differences on extrapyramidal side effect and liver function between them. At the 2nd week, the efficacy of olanzapine was more than that of the risperidon(P<0.05). There were significant difference in electrocardiogram abnormality between olanzapine group and risperidon group(P<0.05).CONCLUSION: There are no significant differences in the efficacy and the electrocardiogram abnormality between two groups. Olanzapine has less side-effect especially. The two drugs adapt to old schizophrenic.

Key words: Olanzapine, Risperidon, Old, Schizophrenia , PANSS, Electrocardiogram

中图分类号:

R749.3

袁国锋, 俞玉礼. 奥氮平治疗老年精神分裂症患者的疗效观察及对心电图的影响[J]. 中国临床药理学与治疗学, 2011, 16(3): 304-308.

YUAN Guo-feng, YU Yu-li. Efficacy and electrocardiogram abnormality of olanzapine in the treatment of old schizophrenic patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 304-308.

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