内源性睡眠促进物质研究进展

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (6): 672-678.

内源性睡眠促进物质研究进展

岳小芳¹, 邱梅红¹, 曲卫敏^2,3, 黄志力^1,2,3

¹复旦大学医学神经生物学国家重点实验室,²上海医学院药理系,³脑科学研究院,上海 200032

收稿日期:2011-04-28 修回日期:2011-05-12 发布日期:2011-07-25
通讯作者: 黄志力,男,教授,博士生导师,研究方向:神经药理学、睡眠医学、神经生物学。 Tel: 021-54237043 E-mail: huangzl@fudan.edu.cn
作者简介:岳小芳,女,博士研究生,研究方向:神经药理学、睡眠医学。 Tel: 021-54237690 E-mail: klyxf@126.com
基金资助:
国家自然科学基金(30625021、30821002、30970955、31070957);“重大新药创制”科技重大专项(2009ZX09303-006);上海市科学技术委员会基金(09PJ1401800、09JC1402500、10XD1400400、10441901600、 11ZR1401800)和上海市重点学科建设项目基金(B119)

Endogenous sleep-promoting substances

YUE Xiao-fang¹, QIU Mei-hong¹, QU Wei-min^2,3, HUANG Zhi-li^1,2,3

¹ State Key Laboratory of Medical Neurobiology, ² Department of Pharmacology, Shanghai Medical College, ³ Institutes of Brain Science, Fudan University, Shanghai 200032, China

Received:2011-04-28 Revised:2011-05-12 Published:2011-07-25

摘要/Abstract

摘要： 睡眠和觉醒的发生及转换可能是脑内神经递质和内源性睡眠促进物质共同作用的结果,同时受昼夜节律调控。Ishimori和Piéron首次发现犬睡眠剥夺后,脑脊液中某种化学物质增多,诱发睡眠,并将其命名为促眠素,即内源性睡眠促进物质。目前已发现前列腺素D₂、核苷、细胞因子、神经肽、激素、胺类衍生物及一氧化氮等二十多种内源性睡眠促进物质。本文综述前列腺素D₂、腺苷、白细胞介素1和肿瘤坏死因子等调节睡眠的作用机制研究进展。

关键词: 内源性睡眠促进物质, 前列腺素D₂, 腺苷, 细胞因子

Abstract: Sleep-wake cycle is regulated by humoral and neuronal mechanism, as well as circadian rhythm. Kuniomi Ishimori and Henri Piéron provided the first experimental evidence for chemical factors that presumably accumulate in the cerebrospinal fluid in dogs after sleep deprivation, and eventually induce sleep. These substances are named hypnotoxin. Accumulated findings show that these endogenous substances include prostanoids, nucleotides, cytokines, neuropeptides, hormones, amine derivatives, nitrogen oxide and so on. This paper presents an overview of current knowledge about the roles of endogenous sleep-promoting substances in the sleep-wake regulation with a focus on prostaglandin D₂, adenosine, interleukin-1, and tumor necrosis factor.

Key words: Endogenous sleep-promoting substances, Prostaglandin D₂, Adenosine, Cytokines

中图分类号:

R338.63

岳小芳, 邱梅红, 曲卫敏, 黄志力. 内源性睡眠促进物质研究进展[J]. 中国临床药理学与治疗学, 2011, 16(6): 672-678.

YUE Xiao-fang, QIU Mei-hong, QU Wei-min, HUANG Zhi-li. Endogenous sleep-promoting substances[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(6): 672-678.

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