Nrf2-ARE通路及其在缺血性心肌损伤中的作用

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (6): 695-698.

Nrf₂-ARE通路及其在缺血性心肌损伤中的作用

徐媛青, 贺海波, 张长城, 王洪武, 袁丁

三峡大学医学院,宜昌 443002,湖北

收稿日期:2011-03-12 修回日期:2011-04-13 发布日期:2011-07-25
通讯作者: 袁丁,男,博士,教授,主要从事中药化学、资源与中药药理研究。 Tel: 0717-6397366 E-mail: 13872639866@163.com
作者简介:徐媛青,女,硕士研究生,主要从事中药心血管药理研究。
基金资助:
国家自然科学基金资助项目(基于体内作用的竹节参抗心肌缺血药效物质基础及资源品质研究: 31070314; 基于谱效关系的中药竹节参质量评价物元模型的研究: 30873383)

Effect of Nrf₂-ARE pathway in the heart ischemic injury

XU Yuan-qing, HE Hai-bo, ZHANG Chang-cheng, WANG Hong-wu, YUAN Ding

Medical Science College, China Three Gorges University, Yichang 443002, Hubei, China

Received:2011-03-12 Revised:2011-04-13 Published:2011-07-25

摘要/Abstract

摘要： Nrf₂-ARE通路是近年来发现的尤为重要的抗氧化应激通路,其信号转导机制复杂而广泛。近年来,研究发现其在缺血性心肌损伤的发病机理中发挥着重要作用,有望成为治疗缺血性心肌损伤的一个新的治疗靶点。本文就其生物学功能及其在缺血性心肌损伤中的作用作一阐述。

关键词: Nrf₂-ARE通路, 缺血性心肌损伤

Abstract: Nrf₂-ARE pathway is particularly important as an anti-oxidative stress pathway in recent years, the mechanism of signal pathway is intricate and general. More research suggests that it plays an important role in the pathogenesis of heart ischemic injury, and it will be an important potential target for treatment of heart ischemic injury. In summary, the physiological and pathophysiological function of Nrf₂-ARE pathway and relation with heart ischemic injury has been reviewed.

Key words: Nrf₂-ARE pathway, Heart ischemic injury

中图分类号:

徐媛青, 贺海波, 张长城, 王洪武, 袁丁. Nrf₂-ARE通路及其在缺血性心肌损伤中的作用[J]. 中国临床药理学与治疗学, 2011, 16(6): 695-698.

XU Yuan-qing, HE Hai-bo, ZHANG Chang-cheng, WANG Hong-wu, YUAN Ding. Effect of Nrf₂-ARE pathway in the heart ischemic injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(6): 695-698.

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Nrf₂-ARE通路及其在缺血性心肌损伤中的作用

Effect of Nrf₂-ARE pathway in the heart ischemic injury

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