乙酰左旋肉碱防治奥沙利铂引起的外周神经病变性疼痛的研究

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (12): 1379-1382.

乙酰左旋肉碱防治奥沙利铂引起的外周神经病变性疼痛的研究

刘国凯¹, Gary Bennett²

¹北京中医药大学东直门医院麻醉科,北京 100700;
²加拿大麦吉尔(McGill)大学麻醉科及疼痛中心,蒙特利尔H3G1Y6,魁北克,加拿大

收稿日期:2011-09-13 修回日期:2011-11-09 出版日期:2011-12-26 发布日期:2012-01-07
作者简介:刘国凯,男,医学博士,副主任医师,研究方向:神经病理性疼痛机制及治疗。Tel: 010-84013316 E-mail: liouguokai@yahoo.com.cn

Acetyl-L-carnitine prevents and reduces oxaliplation-evoked painful peripheral neuropathy

LIU Guo-kai¹, Gary Bennett²

¹Department of Anesthesia, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
²Department of Anesthesia, McGill University, Montred H3G1Y6, Quebec, Canada

Received:2011-09-13 Revised:2011-11-09 Online:2011-12-26 Published:2012-01-07

摘要/Abstract

摘要： 目的: 观察乙酰左旋肉碱(ALCAR)对奥沙利铂引起的外周神经病变性疼痛的防治效果。方法: 选取SD雄性大鼠20只(150~200 g),随机分为两组,ALCAR组与安慰剂组,每组各10只;用5%葡萄糖将奥沙利铂溶液稀释到 2 mg/mL,连续 5 d(d 0~d 4)腹腔注射 2 mg/kg。ALCAR(100 mg/kg, p.o.) 或对照液从0天开始注射(第1天注射奥沙利铂开始),并继续 21 d(即最后一次奥沙利铂注射后再持续 15 d)。并于d 0、d 8、d 15、d 22、d 29、d 35及d 41测定机械异常痛敏[4 g von Frey hairs (VFH)]和机械痛敏(15 g VFH)。结果: 与对照组比较,ALCAR组大鼠在d 8、d 15、d 22、d 29、d 35及d 41机械异常痛敏(4 g VFH)和机械痛敏明显改善(P<0.01)。结论: ALCAR可防治奥沙利铂引起的大鼠外周神经病变性疼痛。

关键词: 乙酰左旋肉碱, 奥沙利铂, 疼痛

Abstract: AIM: To examine the potential efficacy of acetyl-L-carnitine (ALCAR) to prevent and treat oxaliplation-evoked pain.METHODS: 20 adult male Sprague-Dawley rats (150-200 g) were randomly divided into two groups, ALCAR group and control group. Each group had 10 rats. A stock solution of oxaliplatin is diluted to 2 mg/mL with 5% dextrose in distilled water and injected IP at 2 mg/kg on five consecutive days (d 0-d 4) in a volume of 1.0 mL/kg. ALCAR (100 mg/kg; p.o.) or vehicle was given daily starting on day 0 (the day of the first oxaliplatin injection) and continuing until day 21 (i.e.,15 days after the last oxaliplatin injection. Mechano-allodynia and mechano-hyperalgesia were assessed using von Frey hairs with bending forces of 4 g and 15 g, respectively, on d 8, d 22, d 27, d 35, and d 41 postoperatively. Withdrawal responses were counted and expressed as an overall percentage response.RESULTS: Mechano-allodynia (4 g) and mechano-hyperalgesia (15 g) of the rats in ALCAR group were significantly and persistently reduced (P<0.01) on d 8, d 22, d 27, d 35, and d 41 postoperatively in comparison with control group.CONCLUSION: It is concluded that ALCAR may be useful in the prevention and treatment of oxaliplatin-induced painful peripheral neuropathy.

Key words: Acetyl-L-carnitine, Oxaliplation, Pain

中图分类号:

R614
R965.2

刘国凯, Gary Bennett. 乙酰左旋肉碱防治奥沙利铂引起的外周神经病变性疼痛的研究[J]. 中国临床药理学与治疗学, 2011, 16(12): 1379-1382.

LIU Guo-kai, Gary Bennett. Acetyl-L-carnitine prevents and reduces oxaliplation-evoked painful peripheral neuropathy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(12): 1379-1382.

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