肉毒杆菌毒素A辅助复健训练治疗儿童痉挛型脑瘫的疗效观察

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (12): 1423-1425.

肉毒杆菌毒素A辅助复健训练治疗儿童痉挛型脑瘫的疗效观察

吴素英

湖北民族学院附属民大医院儿科,恩施 445000,湖北

收稿日期:2011-10-08 修回日期:2011-11-03 出版日期:2011-12-26 发布日期:2012-01-07
作者简介:吴素英,女,硕士,副主任医师,研究方向:小儿神经康复。E-mail: 1692925897@qq.com

Clinical research on botulinum toxin type A combining rehabilitation training for the treatment of children cerebral palsy

WU Su-ying

Department of Pediatrics, Minda Hospital of Hubei University for Nationalities, Enshi 445000, Hubei, China

Received:2011-10-08 Revised:2011-11-03 Online:2011-12-26 Published:2012-01-07

摘要/Abstract

摘要： 目的: 探讨采用肉毒杆菌毒素A辅助复健训练治疗儿童痉挛型脑瘫的临床疗效。方法: 将本院2009年3月-2011年3月收治的32例脑性瘫痪患儿随机分成2组:对照组16例, 试验组16例。其中,对照组给予常规的复健训练治疗, 试验组则给予注射肉毒杆菌毒素A辅助复健训练治疗。结果: 经过治疗后,试验组的粗大运动(GMFM)功能评分显著高于对照组(P<0.05);试验组的肌张力改良Ashworth评分相比对照组显著性降低(P<0.05);试验组的腘窝角、足背屈角、足外展角的活动范围相比对照组均有显著性改善(P<0.05)。结论: 采用肉毒杆菌毒素A辅助复健训练治疗儿童脑瘫的临床疗效显著。

关键词: 脑瘫, 肉毒杆菌毒素A, 复健训练

Abstract: AIM: To observe the clinical effect of botulinum toxin type A combining rehabilitation for the treatment of children cerebral palsy.METHODS: Thirty-two cases of children cere bral palsy admitted to hospital from March 2009 to March 2011 were randomly divided into two groups, control group(n=16) and treatment group(n=16). The control group was given conventional rehabilitation training; the treatment group was also given injection of botulinum toxin A. The clinical effects in 2 groups were observed and compared.RESULTS: After treatment, the GMFM score in the treatment group was significantly higher than that in the control group (P<0.05). The Ashworth score in the treatment group was significantly lower than that in the control group (P<0.05); and the popliteal fossa angle, foot disaffection angle and abduction angle in the treatment group were superior to those in the control group(P<0.05).CONCLUSION: There is a significant clinical effect of botulinum toxin type A combining rehabilitation for the treatment of children cerebral palsy.

Key words: Cerebral palsy, Botulinum toxin type A, Rehabilitation training

中图分类号:

R748

吴素英. 肉毒杆菌毒素A辅助复健训练治疗儿童痉挛型脑瘫的疗效观察[J]. 中国临床药理学与治疗学, 2011, 16(12): 1423-1425.

WU Su-ying. Clinical research on botulinum toxin type A combining rehabilitation training for the treatment of children cerebral palsy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(12): 1423-1425.