不同剂量维生素D干预治疗方案对婴幼儿血清25-羟维生素D水平的影响

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (12): 1419-1422.

不同剂量维生素D干预治疗方案对婴幼儿血清25-羟维生素D水平的影响

张霞娟¹, 鲍莉芳¹, 鲍舟君², 王英², 李翊卫², 王晔恺³

¹舟山市妇幼保健院儿保科, 舟山 316000,浙江;
²舟山医院检验科, 舟山 316004,浙江;
³舟山医院细胞分子生物学实验室, 舟山 316004,浙江

收稿日期:2011-09-27 修回日期:2011-12-03 出版日期:2011-12-26 发布日期:2012-01-07
通讯作者: 王晔恺,通信作者,男,学士,检验师,研究方向:临床医学检验。Tel: 0580-2558088 E-mail: wangyekai@163.com
作者简介:张霞娟,女,大专,主治医师,研究方向:儿童营养与保健。Tel: 0580-2065223 E-mail: 147488115@qq.com

Dosage research of serum 25-hydroxyvitamin D levels on different intervention treatments for children

ZHANG Xia-juan¹, BAO Li-fang¹, BAO Zhou-jun², WANG Yin², LI Yi-wei², WANG Ye-kai³

¹Child Health Department,the Maternal and Child Care Service Centre of Zhoushan,Zhoushan 316000,Zhejiang,China;
²Clinical Laboratory,Zhoushan Hospital, Zhoushan 316004,Zhejiang,China;
³Molecular and Biology Laboratory,Zhoushan Hospital, Zhoushan 316004,Zhejiang,China

Received:2011-09-27 Revised:2011-12-03 Online:2011-12-26 Published:2012-01-07

摘要/Abstract

摘要： 目的: 比较不同(剂量)维生素D干预治疗方案对血清25-羟维生素D水平的影响。方法: 选取2011年3月至10月血清25-羟维生素D缺乏或相对缺乏的婴幼儿102例,分为以下用药方案:A组:一次性维生素D 15万IU;B组:一次性维生素D 20万IU;C组:一次性维生素D 30万IU;D组:每日维生素A 3600 IU+维生素D 2000 IU,持续1个月。一个月后取清晨空腹血,电化学发光法检测其血清25-羟维生素D水平。结果: A、B、C、D组方案用药后血清25-羟维生素D水平均高于用药前(P＜0.01)。A、B、C组血清25-羟维生素D提升水平均高于D组(P＜0.01);C组血清25-羟维生素D提升水平高于A、B组(P＜0.01)。结论: 一次性维生素D 15～20万IU的是安全有效干预治疗方案。

关键词: 25-羟维生素D, 维生素D缺乏儿童, 电化学发光法

Abstract: AIM: To explore the serum 25-hydroxyvitamin D levels effected by different intervention treatments.METHODS: 102 children with vitamin D deficiency were selected and divided as follows: Group A: VitD 150000 IU once; Group B: VitD 200000 IU once; Group C: VitD 300000 IU once; Group D: VitA 3600 IU+VitD 2000 IU per day, lasting for a month. A month later, their serum 25-hydroxyvitamin D levels were rechecked by electrochemistry method.RESULTS: The serum 25-hydroxyvitamin D levels after treated in Group A,B,C,D were significantly higher than that before treated(P＜0.01). The increased serum 25-hydroxyvitamin D levels in Group A,B and C were significantly higher than that in Group D(P＜0.01). The increased serum 25-hydroxyvitamin D levels in Group C was significantly higher than that in Group A and B(P＜0.01).CONCLUSION: VitD 150000-200000 IU once is a safe and effective intervention treatment for vitamin D deficiency.

Key words: 25-hydroxyvitamin D, Children with vitamin D deficiency, Electrochemistry method

中图分类号:

R723

张霞娟, 鲍莉芳, 鲍舟君, 王英, 李翊卫, 王晔恺. 不同剂量维生素D干预治疗方案对婴幼儿血清25-羟维生素D水平的影响[J]. 中国临床药理学与治疗学, 2011, 16(12): 1419-1422.

ZHANG Xia-juan, BAO Li-fang, BAO Zhou-jun, WANG Yin, LI Yi-wei, WANG Ye-kai. Dosage research of serum 25-hydroxyvitamin D levels on different intervention treatments for children[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(12): 1419-1422.