PTEN和LIVIN在弥漫大B细胞淋巴瘤组织中的表达及临床意义

中国临床药理学与治疗学 ›› 2012, Vol. 17 ›› Issue (4): 376-380.

PTEN和LIVIN在弥漫大B细胞淋巴瘤组织中的表达及临床意义

盛莉莉, 刘银华, 吉兆宁

安徽省皖南医学院附属弋矶山医院, 芜湖 241000,安徽

收稿日期:2011-11-23 修回日期:2012-02-17 发布日期:2012-04-28
通讯作者: 吉兆宁,男,博士,主任医师,教授,研究方向:恶性肿瘤个体化综合治疗。Tel: 13855366810 E-mail: jzning@163.com
作者简介:盛莉莉,女,本科,主治医师,研究方向:实体瘤。Tel: 13605535185 E-mail: shenglili@yahoo.cn

Expression and significance of PTEN and LIVIN in diffuse large B-cell lymphoma

SHENG Li-li, LIU Yin-hua, JI Zhao-ning

Affiliated Hospital,Wannan Medical College,Wuhu 241000,Anhui,China

Received:2011-11-23 Revised:2012-02-17 Published:2012-04-28

摘要/Abstract

摘要： 目的: 探讨PTEN和LIVIN蛋白在弥漫大B细胞淋巴瘤组织中的表达及其临床意义。方法: 选取本院2008年7月至2011年5月初治的弥漫大B细胞淋巴瘤组织标本41例,反应性淋巴结增生21例作为对照组,采用免疫组化S-P法检测PTEN和LIVIN的表达,并探讨PTEN和LIVIN的表达与弥漫大B细胞淋巴瘤的分期及预后的关系。结果: PTEN在弥漫大B细胞淋巴瘤组织中表达率为 39.00%,对照组表达率为 80.95%(P<0.05);LIVIN在弥漫大B细胞淋巴瘤组织中表达率为 65.90％,对照组表达率为 23.81％(P<0.05)。弥漫大B细胞淋巴瘤组织切片PTEN与LIVIN表达存在显著的负相关。PTEN与患者性别、年龄、行为评分、Ann Arbor-Colswolds分期、结外受累、乳酸脱氢酶(LDH)高低、临床B组症状、IPI及病理类型无关。LIVIN表达与患者性别、年龄、Ann Arbor-Colswolds分期及是否有结外受累无关;与行为评分分组、LDH高低、临床是否伴有B组症状、IPI及病理类型有关。结论: PTEN在弥漫大B细胞淋巴瘤中低表达,与弥漫大B细胞淋巴瘤预后无相关性。LIVIN在弥漫大B细胞淋巴瘤中高表达,与患者行为评分分组、LDH高低、临床是否伴有B组症状、IPI及病理类型有关。LIVIN可作为判断弥漫大B细胞淋巴瘤预后的生物学指标。

关键词: PTEN, LIVIN, 免疫组化, 弥漫大B细胞淋巴

Abstract: AIM: To investigate PTEN and LIVIN expression in diffuse large B-cell lymphoma and evaluate their clinical significance. METHODS: From July 2008 to May 2011,41 cases of untreated diffuse large B-cell lymphoma (DLBCL) specimens and 21 cases of benign lymph nodes hyperplasia(BLH) were selected from Affiliated Hospital of Wannan Medical College.The expressions of PTEN and LIVIN in the 41 cases of DLBCL and 21 cases of BLH were measured by means of immunohistochemical S-P staining method and the relationships of PTEN and LIVIN expressions with diffuse large B-cell lymphoma stage and prognosis were evaluated. RESULTS: The positive rate of PTEN expression was 39.00% in the diffuse large B-cell lymphoma tissues,it was 80.95% in the benign lymph nodes hyperplasia tissues(P<0.05). The positive rate of LIVIN expression was 65.90% in the diffuse large B-cell lymphoma tissues,it was 23.81% in the benign lymph nodes hyperplasia tissues(P<0.05). PTEN were not positively related to the patient's gender,age, physical score, clinical stage,extranodular invasion,LDH, International Prognosis Index or the molecular type.LIVIN were not positively related to the patient's gender,age, clinical stage or extranodular invasion(P>0.05). LIVIN were positively related to the patient's physical score,LDH,group B, molecular type and International Prognosis Index(P<0.05). PTEN and LIVIN were inverse correlation in diffuse large B-cell lymphoma. CONCLUSION: There are overexpressions of LIVIN in the diffuse large B-cell lymphoma.PTEN expresses in contrast .The positivity rates of PTEN is related to the group A and molecular type,while LIVIN are related to the patient's physical score,LDH,group B,molecular type and International Prognosis Index. PTEN may not predict the outcome in DLCBL.LIVIN might serve as biomarkers to the diffuse large B-cell lymphoma prognose.

Key words: PTEN, LIVIN, Immunohistochemistry, Diffuse large B-cell lymphoma

中图分类号:

盛莉莉, 刘银华, 吉兆宁. PTEN和LIVIN在弥漫大B细胞淋巴瘤组织中的表达及临床意义[J]. 中国临床药理学与治疗学, 2012, 17(4): 376-380.

SHENG Li-li, LIU Yin-hua, JI Zhao-ning. Expression and significance of PTEN and LIVIN in diffuse large B-cell lymphoma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(4): 376-380.

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