关键词: 冰片, 经鼻腔给药, 灯盏花素, 药代动力学

Abstract: AIM: To investigate the pharmacokinetic effect of Borneol on breviscapine by intranasal administration in rats. METHODS: The plasma concentration of scutellarin at 1,5,10, 30,60,90,120,150,180,210,270 min were measured using ¹²⁵I isotope labeling experiments after the intake of 0.4 mg/kg Breviscapine through intravenous injection, nasal administration and nasal administration co-borneol, drew concentration-time curve and compared pharmacokinetic parameters of three ways. RESULTS: The t_max of co-borneol intranasal administration was 22 min which was significantly shorter than that of simple intranasal administration (30 min).And there is statistically difference between them (t=5.73, P=0.025); the C_max of co- borneol intranasal group and simple intranasal administration group were 0.55, 0.52 μg/mL, and absolute bioavailability were 53.21% and 53.71%, which was not statistically significant. CONCLUSION: To a certain extent,borneol could shorten the peak time of scutellar plasma concentrations in rats by nasal administration, but did not significantly affect the absolute bioavailability,which showed a new research direction on the combination of borneol and breviscapine.

Key words: Borneol, Intranasal administration, Breviscapine, Pharmacokinetics