MicroRNA let-7表达调控机制研究进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (7): 813-817.

MicroRNA let-7表达调控机制研究进展

湛敏, 陈尧, 周宏灏

中南大学临床药理研究所, 长沙 410078, 湖南

收稿日期:2013-01-14 修回日期:2013-03-26 出版日期:2013-07-26 发布日期:2013-06-20
通讯作者: 周宏灏,男,博士生导师,院士,主要从事遗传药理学和临床药理学研究。Tel: 0731-84805379 E-mail: hhzhou@163.com
作者简介:湛敏,女,博士研究生,主要从事遗传药理学和临床药理学研究。Tel: 0731-84805380 E-mail: zhanminhao@163.com
基金资助:
湖南省自然科学基金重点项目(10JJ2008)

Research progress on mechanism of let-7 expression regulation

ZHAN Min, CHEN Yao, ZHOU Hong-hao

Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetìcs, Central South University, Changsha 410078, Hunan, China

Received:2013-01-14 Revised:2013-03-26 Online:2013-07-26 Published:2013-06-20

摘要/Abstract

摘要： MicroRNA let-7调控干细胞分化、调节发育,抑制肿瘤发生发展,这些功能与let-7的表达水平密切相关。研究发现,Lin28、组蛋白去甲基化酶、miR-107和NF90-NF45复合物在转录和转录后水平调控let-7的表达;也存在一些Lin28依赖和Lin28非依赖的调控环路,调节let-7的表达。本文就let-7的调控机制研究进行综述。

关键词: MicroRNA, Let-7, Lin28, 表达调控

Abstract: MicroRNA let-7 regulates stem cell differentiation and normal development, as well act as tumor suppressor. Current studies found it is regulated by Lin28, histone demethylase, miR-107 and NF90-NF45 complex at transcriptional and post-transcriptional level. Furthermore, there are lin28 dependent and -independent regulatory circuits to modulate the expression level of let-7. Here is to make a review on regulation of let-7 expression.

Key words: MicroRNA, Let-7, Lin28, Expression regulation

中图分类号:

R968

湛敏, 陈尧, 周宏灏. MicroRNA let-7表达调控机制研究进展[J]. 中国临床药理学与治疗学, 2013, 18(7): 813-817.

ZHAN Min, CHEN Yao, ZHOU Hong-hao. Research progress on mechanism of let-7 expression regulation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(7): 813-817.

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