孕甾烷X受体在药物代谢中的作用及研究进展

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (10): 1169-1174.

孕甾烷X受体在药物代谢中的作用及研究进展

张轶雯¹, 鲍美华¹, 周丽华², 周宏灏¹

¹中南大学临床药理研究所,长沙 410008,湖南;
²长沙市中心医院呼吸内科,长沙 410004,湖南

收稿日期:2012-10-10 修回日期:2013-07-08 出版日期:2013-10-26 发布日期:2013-09-30
通讯作者: 周宏灏,男,中国工程院院士,博士生导师,研究方向:遗传药理学和临床药理学。Tel: 0731-84805380 E-mail: hhzhou2003@163.com
作者简介:张轶雯,女,博士,研究方向:临床药理学。Tel: 0731-84805380 E-mail: zjzyw2003@163.com
基金资助:
重大新药创制专项临床前药物代谢动力学技术平台资助项目(20092X0950L032,2009ZX09304-003);湖南省教育厅科学研究项目(11C0152 )

Function of pregnane X receptor in drug mechanism and research progress

ZHANG Yi-wen¹, BAO Mei-hua¹, ZHOU Li-hua², ZHOU Hong-hao¹

¹Institute of Clinical Phormacology, Central South Vniversity, Changsha 410008, Hunan, China;
²Department of Respiratory, Changsha Center Hospital, Changsha 410004, Hunan, China

Received:2012-10-10 Revised:2013-07-08 Online:2013-10-26 Published:2013-09-30

摘要/Abstract

摘要： 孕甾烷X受体(Pregnane X receptor, PXR)为核受体超家族中NR1I亚家族成员,于肝脏和肠道中广泛表达。该受体作为药物代谢的关键调控因子广泛参与药物的吸收、分布、代谢及排泄过程。本文从药物代谢角度分别对PXR参与调节的Ⅰ、Ⅱ相代谢酶及转运体进行介绍,为临床药物相互作用及针对PXR为靶点的药物研发提供参考。

关键词: 孕甾烷X受体, 药物代谢, 调节

Abstract: Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily NR1I subfamily, which is widely expressed in the liver and the intestine. The receptor as a key regulator of drug metabolism are widely involved in drug absorption, distribution, metabolism and excretion process.This review will introduce Ⅰ, Ⅱ phase metabolizing enzymes and transporters in the regulation of PXR. It will provide part of the basis for clinical drug interaction and drug research and development for PXR as a target.

Key words: Pregnane X receptor, Drug metabolism, Regulation

中图分类号:

R969

张轶雯, 鲍美华, 周丽华, 周宏灏. 孕甾烷X受体在药物代谢中的作用及研究进展[J]. 中国临床药理学与治疗学, 2013, 18(10): 1169-1174.

ZHANG Yi-wen, BAO Mei-hua, ZHOU Li-hua, ZHOU Hong-hao. Function of pregnane X receptor in drug mechanism and research progress[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(10): 1169-1174.

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