坎地沙坦对自发性高血压大鼠胰岛素抵抗及血清脂联素的影响

中国临床药理学与治疗学 ›› 2013, Vol. 18 ›› Issue (11): 1201-1204.

• 基础研究 • 下一篇

坎地沙坦对自发性高血压大鼠胰岛素抵抗及血清脂联素的影响

黎小妍, 张平, 陶玲, 刘玉兴

中山大学附属第三医院药剂科,广州 510630,广东

收稿日期:2012-11-13 修回日期:2013-08-29 出版日期:2013-11-26 发布日期:2013-11-22
通讯作者: 张平,女,本科,副主任药师,研究方向:药学分析和临床药理学。Tel: 020-85253221 E-mail: zp_0701@yahoo.com
作者简介:黎小妍,女,博士研究生,主管药师,研究方向:药学分析和临床药理学。Tel: 020-85253221 E-mail: lxyzzj@126.com
基金资助:
国家自然青年科学基金(81200094); 广东省医学科研基金(B2012112); 广东省自然科学基金(S2012040006228); 广东省教育厅学科建设专项育苗工程项目(2012LYM-0004)

Effect of candesartan on HOMA-IR and serum adiponectin of spontaneously hypertensive rats

LI Xiao-yan, ZHANG Ping, TAO Ling, LIU Yu-xing

Department of Pharmacy, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China

Received:2012-11-13 Revised:2013-08-29 Online:2013-11-26 Published:2013-11-22

摘要/Abstract

摘要： 目的: 探讨血管紧张素II受体拮抗剂坎地沙坦对自发性高血压大鼠(SHR)糖代谢及血清脂联素的影响。方法: SHR大鼠分为两组:高血压组(SHR,n=30);坎地沙坦组(坎地沙坦,1 mg·kg^-1·d^-1,n=30, 灌胃法给药),另设同种系WKY大鼠为对照组,给予同等量安慰剂, 12周后分别用生化方法和放射免疫方法测定空腹血糖(FBG)和胰岛素水平(FINS),计算IR指数(HOMA-IR),用生化方法进行口服葡萄糖耐量试验(OGTT),ELISA分析法测定血清脂联素水平。结果: 空腹血糖高血压组和对照组大鼠差异无统计学意义(P>0.05);空腹胰岛素水平和HOMA-IR与高血压组大鼠相比,对照组和坎地沙坦组要明显降低 (P<0.05);OGTT结果显示,30 min 和 120 min 血糖水平与高血压组相比,对照组和坎地沙坦给药组明显降低(P<0.05)。血清脂联素的水平与高血压组相比,对照组和坎地沙坦大鼠明显较高(P<0.05)。结论: 血管紧张素II 受体拮抗剂坎地沙坦可以升高高血压血清脂联素水平,改善IR,降低30、120 min 餐后血糖水平。

关键词: 坎地沙坦, 脂联素, 自发性高血压, 胰岛素抵抗

Abstract: AIM: To investigate the effect of candesartan, an angiotensin II receptor antagonist, on HOMA-IR and serum adiponectin of spontaneously hypertensive rats(SHRs).METHODS: SHRs were divided into two groups: Hypertension group (SHR, n=30), Candesartan group (Candesartan, 1 mg·kg^-1·d^-1, n=30, gavaging for 12 weeks).WKY rats were the control group(WKY, n=30). The other two groups were given a placebo. Fasting blood glucose and serum insulin were measured by biochemistry methods, insulin resistance index (HOMA-IR) was calculated,OGTT was tested by biochemistry methods. Changes of serum adiponectin were measured by ELISA.RESULTS: No difference in the fasting blood glucose of the three groups (P>0.05) was observed. Serum insulin level and HOMA-IR of SHRs were higher than those of WKY and drug groups (P<0.05). Candesartan could not reduce those of SHRs. Serum adiponectin level of SHRs was lower than that of WKY, and candesartan could obviously increase that of SHRs (P<0.05). The result of OGTT showed that blood glucose level at 30 min or 120 min in hypertension group compared with control group and candesartan group were higher.CONCLUSION: Candesartan could ameliorate the upregulaiton of serum adiponectin in SHR, improve insulin resistance and reduce blood glucose level of SHR at 30 min and 120 min.

Key words: Candesartan, Adiponectin, Spontaneously hypertension, Glycometabolism

中图分类号:

R965.2

黎小妍, 张平, 陶玲, 刘玉兴. 坎地沙坦对自发性高血压大鼠胰岛素抵抗及血清脂联素的影响[J]. 中国临床药理学与治疗学, 2013, 18(11): 1201-1204.

LI Xiao-yan, ZHANG Ping, TAO Ling, LIU Yu-xing. Effect of candesartan on HOMA-IR and serum adiponectin of spontaneously hypertensive rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(11): 1201-1204.

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坎地沙坦对自发性高血压大鼠胰岛素抵抗及血清脂联素的影响

Effect of candesartan on HOMA-IR and serum adiponectin of spontaneously hypertensive rats

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