米诺环素联合vitapex糊剂治疗持续性根尖周炎的临床研究

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (2): 170-173.

米诺环素联合vitapex糊剂治疗持续性根尖周炎的临床研究

周淑珍¹，高云云²，谢静²，高孟飞¹

¹慈溪市人民医院口腔科，慈溪 315300，浙江；²温州医科大学附属第一医院口腔科，温州 325000，浙江

收稿日期:2016-11-30 修回日期:2015-08-01 出版日期:2017-02-26 发布日期:2017-03-02
作者简介:周淑珍，女，主治医师，主要从事口腔疾病的治疗及研究。 Tel:15057687300 E-mail:z927057913081@163.com
基金资助:
温州市科技局项目（Y20130260）

Clinical trial of minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis

ZHOU Shuzhen¹, GAO Yunyun², XIE Jing ², GAO Mengfei ¹

¹Department of Stomatology, Peoples Hospital of Cixi City, Cixi 315300, Zhejiang, China; ² Department of Stomatology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang, China

Received:2016-11-30 Revised:2015-08-01 Online:2017-02-26 Published:2017-03-02

摘要/Abstract

摘要：

目的:观察盐酸米诺环素联合vitapex糊剂治疗持续性根尖周炎的临床疗效和安全性。方法: 102例持续性根尖周炎患者按随机数字表法分为对照组51例和试验组51例，对照组采用碘仿氢氧化钙糊剂治疗，试验组采用vitapex糊剂一次根管和盐酸米诺环素软膏治疗，于治疗后2周和3个月，观察患者的临床疗效和不良反应，视觉模拟评分法(VAS)评价疼痛程度，ELISA检测外周血炎症因子水平。结果:2周试验组患者总有效率为86.27%，明显高于对照组的64.71%（ χ2=6.411, P=0.011）；3个月试验组患者总有效率为94.12%，明显高于对照组的70.59%（χ2=9.714, P=0.002）。治疗后，两组患者的VAS均降低，3个月VAS明显低于2周，且试验组VAS明显低于对照组，差异有统计学意义（P<0.01）。治疗后两组患者TNF-α、IL-2和IL-8水平均降低，3个月明显低于2周，且试验组明显低于对照组，差异有统计学意义（P<0.05）。两组患者均未见明显不良反应和不适症状。结论:盐酸米诺环素联合Vitapex糊剂可减轻患者的疼痛程度，降低炎症反应，临床疗效确切，且安全性较好，值得推广应用。

关键词: 持续性根尖周炎, 米诺环素, vitapex糊剂, 临床疗效, 不良反应

Abstract:

AIM: To observe the clinical efficacy and safety of minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis. METHODS: One hundred and two patients with persistent apical periodontitis were divided into control group (n=51) and treatment group (n=51) according to random number table method. The control group was treated with calcium hydroxide iodoform paste, and the treatment group was treated with vitapex paste a root canal combined with minocycline hydrochloride ointment. After 2 weeks and 3 months treatment, the clinical curative effect and adverse reaction were observed, the degree of pain was evaluated by visual analogue scale (VAS), and the levels of peripheral inflammatory factor were detected by ELISA. RESULTS: After two weeks, the total effective rate in treatment group was significantly higher than the control group (χ²=6.411, P=0.011). After 3 months, the total effective rate 94.12% in treatment group was significantly higher than the control group 70.59%(χ²=9.714, P=0.002). After treatment the VAS was lower than before treatment in two groups, the VAS of 3 months was significantly less than 2 weeks, and the VAS in treatment group was obvious lower than the control group, the difference was statistically significant (P<0.01). After treatment the levels of TNF-α, IL-2 and IL-8 were lower than before treatment in two groups, the levels of TNF-α, IL-2 and IL-8 of 3 months were significantly less than 2 weeks, and the treatment group was obvious lower than the control group, the difference was statistically significant (P<0.05). Two groups of patients were not seen obvious adverse reactions and discomfort symptoms. CONCLUSION: The minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis can reduce the patient's pain, decrease inflammation, increase clinical efficacy, and is relatively safe, which is worthy of popularization and application.

Key words: persistent apical periodontitis, minocycline hydrochloride, vitapex paste, clinical curative, adverse reactions

中图分类号:

R781.34

周淑珍，高云云，谢静，高孟飞. 米诺环素联合vitapex糊剂治疗持续性根尖周炎的临床研究[J]. 中国临床药理学与治疗学, 2017, 22(2): 170-173.

ZHOU Shuzhen, GAO Yunyun, XIE Jing, GAO Mengfei. Clinical trial of minocycline hydrochloride combined with vitapex paste in the treatment of persistent apical periodontitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 170-173.

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