关键词: 个体化用药, 抗感染, 药动学模型, 临床药师

Abstract:

AIM: To explore the role of clinical pharmacists participating in the individualized anti-infective therapy after anterior cruciate ligament reconstruction.  METHODS: Clinical pharmacists participated in the therapy for a patient with staphylococcus aureus infection after anterior cruciate ligament reconstruction.  According to patient's condition, clinical pharmacist assisted physicians to formulate preliminary anti-infection plan.Embarking on drug sensitivity test, clinical pharmacist carried out individualized medication for patient by vancomycin serum concentration monitoring and population pharmacokinetic modeling. Close pharmaceutical care were conducted throughout the therapy. Moreover, clinical pharmacist assisted physicians to evaluate the therapeutic efficacy. RESULTS: According to vancomycin serum concentrations, clinical pharmacist suggested physician to change the anti-infection plan, and received a good therapeutic effect. CONCLUSION: Clinical pharmacists participate in the anti-infective therapy after anterior cruciate ligament reconstruction, and the designs of individualized dosing regimens contribute in the safety and effectiveness of drug use in patients with serious infection.

Key words: individualized medicine, anti-infective therapy, pharmacokinetic modeling, clinical pharmacists