Progress in the treatment of dermatomyositis

doi:10.12092/j.issn.1009-2501.2018.07.019

Abstract

Abstract:

Dermatomyositis is an autoimmune disease that mainly affects the skin and muscles. Systemic glucocorticoids is currently the first-line therapy of this disease. Combination of immunosuppressants helps to improve clinical efficacy and reduce the dosage of glucocorticoid, such as methotrexate, azathioprine, leflunomide, tacrolimus and mycophenolate mofetil. For some refractory cases without any response to the treatments of glucocorticoids and immunosuppressants, biologic agents (such as rituximab, abatacept, tocilizumab, infliximab), intravenous immunoglobulin, or plasma exchange are recommended. However, it is necessary to further demonstrate the clinical efficacy of some immunosuppressants and biologic agents on dermatomyositis in a lot of larger clinical trials.

Key words: dermatomyositis, glucocorticoids, immunosuppressive agents, intravenous immunoglobulin, plasma exchange, biological agents

CLC Number:

R593.26

LU Xiaohong，WANG Peiguang. Progress in the treatment of dermatomyositis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(7): 836-840.

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