Research progress on effects of sevoflurane anesthesia on developing brain

doi:10.12092/j.issn.1009-2501.2022.12.002

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2022, Vol. 27 ›› Issue (12): 1333-1339.doi: 10.12092/j.issn.1009-2501.2022.12.002

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Research progress on effects of sevoflurane anesthesia on developing brain

FAN Di, SHI Cuina, YANG Qingqing, JI Muhuo

Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210003, Jiangsu, China

Received:2022-08-23 Revised:2022-12-27 Online:2022-12-26 Published:2023-01-13

Abstract

Abstract:

Sevoflurane is a commonly used inhalation anesthetic in children's general anesthesia, which may have some adverse effects on brain development. This review discusses the effects of sevoflurane anesthesia on developing brain, based on the characteristics of developing brain tissue, the effects on developing brain function, the mechanism of sevoflurane neurotoxicity and the strategies to reduce sevoflurane anesthesia neurotoxicity, so as to provide reference for clinical application.

Key words: sevoflurane, developmental brain, neurotoxicity

CLC Number:

R614

FAN Di, SHI Cuina, YANG Qingqing, JI Muhuo. Research progress on effects of sevoflurane anesthesia on developing brain[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(12): 1333-1339.

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Research progress on effects of sevoflurane anesthesia on developing brain

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