关键词: 音乐, 不良心血管事件危险因素, 血压

Abstract: Objective To observe the early continued exposure to music environment on blood pressure and the incidence of adverse cardiovascular events of rats in adulthood. Methods 20 male SD rats was exposed to music (Mozart 《G minor Symphony No.fortieth》) in 24h after birth,the same age SD rats as control group,keeping the same conditions but without music.In 5~8 weeks,blood pressure was monitored by noninvasive method daily.Afer 8 weeks,rats were sacrificed,aortic endothelial morphology was observed by scanning electron microscope and angiotensin II (Ang II),C reactive protein (CRP),plasminogen activator inhibitor -1 (PAI-1),plasma brain natriuretic peptide (BNP) in serum was determined by ELISA. Results The rats of music group and control had no significant differences in weight and heart rate.Systolic and mean arterial pressure decreased in rats of music group,but without statistical significance.The aortic endothelial morphology of rats of music group was better,with no fiber attachment;that of control group was also normal,but some of the cell connection was missing,and with more endometrial attachment.The serum CRP,PAI-1 of rats of music group decreased significantly (P<0.05).Ang Ⅱ,BNP had a decreasing tendency,but no significant differences were found between the two groups. Conclusion The early continuous exposure to music environment demonstrated beneficial effects on the cardiovascular system in developing rats.The decreasement of blood pressure of adult rats is not very significant,but its propensity of occurrence of adverse cardiovascular events had been greatly reduced.

Key words: music, risk of adverse cardiovascular events, blood pressure