中国儿童保健杂志 ›› 2015, Vol. 23 ›› Issue (6): 647-649.DOI: 10.11852/zgetbjzz2015-23-06-27

• 经验交流 • 上一篇    下一篇

孤独症谱系障碍病因影响因素分析

马居飞1,匡桂芳2,衡中玉2,赵永生1,马爱国1,韩秀霞1   

  1. 1 青岛大学公共卫生学院,山东 青岛 266021;
    2 青岛市妇女儿童保健中心心理卫生科,山东 青岛 266021
  • 收稿日期:2014-11-27 发布日期:2015-06-10 出版日期:2015-06-10
  • 通讯作者: 韩秀霞,E-mail:hanxiuxia57@sina.com
  • 作者简介:马居飞(1988-),女,山东人,在读研究生,主要研究方向为儿少卫生与妇幼保健学专业。
  • 基金资助:
    青岛市科技局科研基金资助项目(KJZD-12-22-nsh)

Study on factors of childhood autism spectrum disorder

MA Ju-fei1,KUANG Gui-fang2,HENG Zhong-yu2,ZHAO Yong-sheng1,MA Ai-guo1,HAN Xiu-xia1   

  1. 1 Public Health School of Qingdao University,Qingdao,Shandong 266021,China;
    2 Department of Psychology,Qingdao Medical Center for Women and Children,Qingdao,Shandong 266021,China
  • Received:2014-11-27 Online:2015-06-10 Published:2015-06-10
  • Contact: HAN Xiu-xia,E-mail:hanxiuxia57@sina.com

摘要: 目的 探讨孤独症谱系障碍发病的影响因素,为孤独症谱系障碍的病因、发病机制及防治提供依据。方法 采用自制的孤独症谱系障碍影响因素调查表对80例孤独症谱系障碍患儿和80例正常儿童进行病例对照研究。结果 经非条件多因素回归分析结果显示,有统计学意义的各个危险因素中,对孤独症谱系障碍发病的影响值从大到小依次为:过期产(OR=20.396,P<0.01),人工喂养(OR=7.567,P<0.01),新生儿黄疸(OR=7.234,P<0.01),宫内或新生儿缺氧(OR=6.411,P<0.05),孕期接触不良因素(OR=3.354,P<0.01),塑料玩具(OR=3.115,P<0.01),母亲性格内向(OR=2.086,P<0.05),而常规的家庭教育为保护因素(OR=0.093,P<0.01)。结论 孤独症谱系障碍儿童的发病可能与遗传,环境因素,孕期和出生高危因素存在一定关系,控制这些因素可能会降低孤独症谱系障碍的发生。

关键词: 孤独症谱系障碍, 孤独症, 影响因素, 危险因素, 儿童

Abstract: Objective To investigate the risk factors affecting children with autism spectrum disorder (ASD) and to offer basis for etiology,pathogenesis and prevention for ASD. Methods A total of 80 children with ASD and 80 normal children were investigated in this case-control study.Risk factors were obtained through self-administered questionnaires which were completed by parents. Results Logistic analysis according to their contributive values showed the risk factors were postterm delivery (OR=20.396,P<0.01),atificial feeding (OR=7.567,P<0.01),neonatal jaundice (OR=7.234,P<0.01),hypoxia (OR=6.411,P<0.05),risk factors during pregnancy (OR=3.354,P<0.01),plastic toys (OR=3.115,P<0.01) and mother's introversion character (OR=2.086,P<0.05).However,regular family education was the protect factor. Conclusions The environment factors,the unfavorable events in pregnant and delivery,the neonatal and developmental phase could increase the incidence of autism spectrum disorder.Some effective should be taken to control these risk factors.

Key words: autism spectrum disorder, autism, influencing factor, risk factor, childhood

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