卵胞浆内单精子注射子代4岁龄智能发育情况分析

doi:10.11852/zgetbjzz2016-24-03-04

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (3): 235-237.DOI: 10.11852/zgetbjzz2016-24-03-04

卵胞浆内单精子注射子代4岁龄智能发育情况分析

洪琴¹，池霞^1，2，杨蕾¹，张敏¹，刘晓¹，张蕾¹，乌兰¹，凌秀凤¹，赵纯¹，解雅春¹，陈荣华²，郭锡熔^1，2，童梅玲^1，2

1 南京医科大学附属南京妇幼保健院生殖医学国家重点实验室，南京江苏 210004;
2 南京医科大学儿科医学研究所，南京江苏 210029

收稿日期:2015-06-29 发布日期:2016-03-01 出版日期:2016-03-01
通讯作者: 池霞,E-mailchixia2001@njmu.edu.cn
作者简介:洪琴(1982-)，女，江苏人，主治医师，博士学位，主要研究方向为发育行为儿科学，儿童神经心理。
基金资助:
国家自然科学基金(81250008);中国疾病预防控制中心妇幼保健中心“2015年度合生元母婴营养与健康研究项目”(2015FYH011);江苏省医学重点人才项目(RC2011022);南京市医学科技发展项目(201108007)

Cognitive development of 4 years old children conceived by intracytoplasmic sperm injection.

HONG Qin¹,CHI Xia^1,2,YANG Lei¹,ZHANG Min¹,LIU Xiao¹,ZHANG Lei¹,WU Lan¹,LING Xiu-feng¹, ZHAO Chun¹,XIE Ya-chun¹,CHEN Rong-hua²,GUO Xi-rong^1,2,TONG Mei-ling^1,2.

1 State Key Laboratory of Reproductive Medicine,Department of Pediatrics,Nanjing Maternal and Child Health Care Hospital of Nanjing Medical University,Nanjing,Jiangsu 210004,China;
2 Institute of Pediatrics of Nanjing Medical University,Nanjing,Jangsu 210029,China

Received:2015-06-29 Online:2016-03-01 Published:2016-03-01
Contact: CHI Xia,E-mail:chixia2001@njmu.edu.cn

摘要/Abstract

摘要： 目的分析卵胞浆内单精子注射(ICSI)子代4岁龄智能发育情况。方法选取2009年1月-2009年12月在南京市妇幼保健院进行卵胞浆内单精子注射的单胎活产子代作为研究对象(ICSI，n=18例)，以年龄、性别为匹配条件，选取该院出生的自然受孕单胎活产婴儿为作对照组(SC，n=36例);排除标准:孕周<32周，体重<1 500g，有宫内窘迫，出生窒息史者。利用中国韦氏学前儿童智力量表(C-WPPSI)分别比较两组儿童4岁龄的智力发育水平。结果比较两组儿童4岁龄智能发育水平后发现，韦氏智力测验中ICSI子代总智商、言语智商及操作智商均值在正常范围，但得分均低于SC组(总智商:ICSI 100.67±11.45，SC 115.33±10.82;言语智商:97.72±14.21，111.72±12.40;操作智商:104.83±7.87，116.50±10.68)，两者差异具有统计学意义(P<0.05)。进一步分析两组智力异常的发生率，发现ICSI子代图画填充项目量表分<7的人数明显高于SC组(ICSI 4/18，SC 0/36，χ²=8.64，P<0.05)。结论有限的样本量结果提示，ICSI子代4岁龄智能发育在正常范围，但韦氏智力测验IQ值低于SC组。ICSI子代远期智能情况需要通过更广泛、长期、系统的随访跟踪才能得出更为详实的结论。

关键词: :辅助生殖技术, 卵胞浆内单精子注射, 子代, 智能

Abstract: Objective To analyse the cognitive development of 4 year old children conceived by intracytoplasmic sperm injection (ICSI). Methods Children enrolled into our study were conceived by ICSI from January 2009,through to the end of December 2009 in the State key Laboratory of Reproductive Medicine Department of Nanjing Maternal and Child Health Care Hospital.18 ICSI alive single born underwent cognitive assessments and 36 spontaneously conceived (SC) singletons as control subjects were matched with respect to age,gender,and birth number.The children were excluded if their gestational weeks less than 32 weeks,birth weight less than 1 500 g,with fetal distress or birth asphyxia history.Children's cognitive development was assessed with the Chinese-Wechsler preschool and primary scale of intelligence (C-WPPSI). Results Singletons conceived by ICSI achieved lower IQ scores than SC singletons (full-scale IQ:ICSI 100.67±11.45,SC 115.33±10.82; verbal IQ:97.72±14.21,111.72±12.40;performance IQ:104.83±7.87,SC 116.50±10.68,P<0.05).However,ICSI children obtained lower scores on the "picture completion" subtests (ICSI 4/18,SC 0/36,χ²=8.64,P<0.05). Conclusion In the relatively limited sample investigated,cognitive development among ICSI singletons is lower than SC singletons.By refining assessment content,expanding the sample size and extending follow-up time,we can provide more powerful evidence for judgment of the long-term developmental outcomes of assisted reproductive offspring.

Key words: assisted reproductive technology, intracytoplasmic sperm injection, offspring, cognitive

中图分类号:

R179

洪琴，池霞，杨蕾，张敏，刘晓，张蕾，乌兰，凌秀凤，赵纯，解雅春，陈荣华，郭锡熔，童梅玲. 卵胞浆内单精子注射子代4岁龄智能发育情况分析[J]. 中国儿童保健杂志, 2016, 24(3): 235-237.

HONG Qin,CHI Xia,YANG Lei,ZHANG Min,LIU Xiao,ZHANG Lei,WU Lan,LING Xiu-feng, ZHAO Chun,XIE Ya-chun,CHEN Rong-hua,GUO Xi-rong,TONG Mei-ling. Cognitive development of 4 years old children conceived by intracytoplasmic sperm injection.[J]. journal1, 2016, 24(3): 235-237.

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卵胞浆内单精子注射子代4岁龄智能发育情况分析

Cognitive development of 4 years old children conceived by intracytoplasmic sperm injection.

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