关键词: 妊娠期糖尿病, 新生儿, 肾功能

Abstract: Objective To investigate the effect of gestation diabetes mellitus(GDM) on the renal function in newborn within 7 days. Methods All the cases involved in this study were neonates borned in Foshan Maternal and Child Health Care Hospital from July 2014 to June 2015,60 cases whose mother had suffered from GDM were selected into the observation group,and other 60 cases who were borned in the same period were selected into the control group,and whose mother had not suffered from GDM.The levels of BUN,CREA,Cystatin C (Cys-C),β₂-microglobulin(β₂-MG) in serum were detected and compared in day 1,3 and 7. Results Compared with the control group,the levels of Cys-C and β₂-MG in observation group were higher in day 1 (P<0.05),neither BUN nor CREA levels had significant change (P>0.05).The levels of β₂-MG were higher in day 3 and 7 (P<0.05),but the levels of Cys-C had no significant changes (P>0.05).For the term infants,the level of β₂-MG was higher in observation group (P<0.05),the level of Cys-C was higher only in day 1 (P<0.05);For the preterm infants,the level of β₂-MG was higher in observation group in day 3 (P<0.05),the level of Cys-C was higher only in day 1 (P<0.05). Conclusions There is renal damage in neonates borned by GDM mothers,but the neonatal renal function improved within 1 weeks,and the level of Cys-C returned to normal earlier than β₂-MG.

Key words: gestational diabetes mellitus, neonate, renal function