关键词: 肥胖, 血清分泌型卷曲相关蛋白5, 代谢综合征, 脂肪因子, 儿童

Abstract: Objective To evaluate the associations of secreted frizzled-related protein 5(SFRP5),a novel anti-inflammatory adipokine with childhood metabolic syndrome (MS) and the effects of lifestyle interventions on circulating SFRP5 levels in children. Methods A study was conducted among 111 obese children and 49 lean controls,and the height,weight,waist circumference and blood pressure were measured.The blood lipid,blood glucose,and biochemical test were also tested.Venous blood was reserved to detect serum insulin,SFRP5,Wnt5a,hsCRP,leptin and adiponectin.A lifestyle intervention was performed in a subgroup of 31 obese children for 6 months.Indexes were measured at baseline and after lifestyle intervention. Results SFRP5 was significantly lower in obese children with MS compared with other two groups (P<0.05).SFRP5 was negatively correlated with homeostasis model assessment of insulin resistance (HOMA-IR) and leptin/adipo reception (LAR),and was positively correlated with adiponectin after control age and body mass index (BMI) (P<0.05).Furthermore,changes in BMI,blood pressure,HOMA-IR,triglyceride (TG),leptin,LAR were significantly increased,and SFRP5 and adiponectin were decreased after weigh loss intervention among 31children (P<0.05). Conclusions Serum SFRP5 is related with body lipid especially central obesity,lipid disorder,hypertension and hyperinsulinemia.It may be a beneficial adiposity factor which could improve the disorder of body.   

Key words: obesity, secreted frizzled-related protein 5, metabolic syndrome, adipokine, children