关键词: 体外受精-胚胎移植, 双胎妊娠, 新生儿

Abstract: Objective To explore the differences of clinical characteristics between in vitro fertilization-embryo transfer (IVF-ET) twins and natural pregnancy twins,and provide guidance for clinical management of IVF-ET twins. Methods Totally 172 pairs of twins after IVF-ET and 476 pairs of natural pregnancy twins were selected as the research objects,the data about their gender,maternal age,birth length,birth weight,premature,gestational age,neonatal complications,NICU admission rate,neonatal mortality and morbidity were collected,and the differences between the two groups were compared. Results The average maternal age,the twin birth weight discordance,the birth weight discordance rate,neonatal hypoglycemia/hyperglycemia,neonatal infection,neonatal heart related disease,respiratory disease of IVF-ET twins were higher than those of the natural pregnancy group(P＜0.05).The gestational age of the IVF-ET group was less than the natural pregnancy group(P＜0.05). Conclusion Postoperative IVF-ET newborn monitoring should be strengthened.We should pay attention to the occurrence of neonatal blood glucose abnormalities,neonatal infection,neonatal heart related diseases and respiratory disease,and try to focus on aforementioned symptoms at early stage actively so as to prevent undesirable outcomes.

Key words: in vitro fertilization-embryo transfer, twin pregnancy, newborn