关键词: 癫痫, 睡眠期癫痫电持续状态, 左乙拉西坦, 临床疗效

Abstract: Objective To explore the efficacy of the Levetiracetam treatment of Electrical Status Epilepticusin in Sleep(ESES). Methods Totally 50 cases of epilepsy children with ESES were treated with Levetriacetam add-on therapy (13 cases) and monotherapy (37 cases).The clinical seizures,long-term video EEG and intelligence were observed before and after therapy to analyse the eliminate of the ESES,the controlling of the role of clinical seizures,and the influence of Levetiracetam on the cognition. Results 2 cases were lost to follow-up,48 cases were finished at least 1 year of follow-up.The seizures of 29 patients were completely controlled,8 cases reduced more than 50%,11 cases were invalided.The clinical effective rate was 77.1%,the reduce of more than 75% of Spike Wave Index (SWI) were 14 cases (29.2%),that of more than 50% of SWI were 11 cases(22.9%),the total effective rate was 52.1%.There were no significant difference on the operation ability,verbal ability and total IQ before and after treatment.The effective rate of the treatment of atypical benign epilepsy with central and temporary (ABECT) was 69.6%,significantly higher than other syndromes. Conculsions Levetiracetam is efficient and safety.Long-term treatment of levetiracetam has no cognitive impairment of the children.Levetiracetam is more efficient to patients with ABECT than other epileptic syndrome.

Key words: epilepsy, electrical status epilepticus in sleep, Levetiracetam, clinical efficiency