关键词: C肽, 胰岛素, 皮质醇, 新生儿低血糖

Abstract: Objective To analyze the correlation of C-peptide,insulin,cortisol with neonatal hypoglycemia.Methods Totally 258 cases of newborns with hypoglycemia admitted to hospital from January 2015 to February 2016 were selected as the research objects.Another 80 cases of newborns with normal blood glucose were selected as contrast group.C-peptide,insulin and cortisol level were compared between the hypoglycemia group and the normal group to analyze the correlation of C-peptide,insulin,cortisol level,hypoglycemia duration time with hypoglycemia value.Results The levels of C-peptide and insulin of newborns in the hypoglycemia group were higher than those of the normal group,and the cortisol level was significantly lower than that of the normal group (P<0.05).C-peptide,insulin and hypoglycemia duration were positively correlated (r=0.748,0.814,all P<0.001);Cortisol levels were negatively correlated with duration of hypoglycemia (r=-0.809,P<0.001).There was a positive correlation between the values of C- peptide,insulin and hypoglycemia (r=0.832,0.786,all P<0.001) and cortisol level was negatively correlated with the values of hypoglycemia (r=-0.623,P<0.001).Conclusions The occurrence of neonatal hypoglycemia correlate with C-peptide,insulin,and cortisol.For newborns with abnormal levels of C-peptide,insulin and cortisol,special attention should be paid to prevent hypoglycemia though the test of hypoglycemia is normal so as to decrease misdiagnosis and to reduce the incidence of neonatal hypoglycemia sequelae.

Key words: C-peptide, insulin, cortisol, neonatal hypoglycemia