关键词: 孕晚期, 睡眠, 子代, 胰岛素, 胰岛素抵抗

Abstract: Objective To determine the association among maternal sleep in late pregnancy, insulin level, and insulin resistance in offspring at the age of 2 years old by establishing a birth cohort. Methods Totally 255 healthy late pregnancy women (pregnant for 36~38 weeks) and their infants were recruited in this prospective cohort study from Renji Hospital in Shanghai. Actigraph was used to measure sleep parameters in women during late pregnancy. Random venous blood was collected at 2 years of follow-up in children for measuring glucose and insulin levels. Insulin resistance was assessed using homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA-IR=[glucose (mmol/l)×insulin (uU/ml)]/22.5. Results The levels of glucose, insulin and HOMA-IR were (4.58 ±0.53) mmol / L, (4.65 ±3.61) μU / ml and (0.98 ±0.84) respectively in children at the age of 2 years old. After adjustment for maternal age in late pregnancy, educational level, family income and children′ gender, the longer wake time after sleep onset of late pregnancy women at night, the higher insulin level(β=0.236,P=0.016) and higher insulin resistance (β=0.241,P=0.015) were observed in offspring at the age of 2 years old. Conclusions The wake time after sleep onset of late pregnancy women is significantly associated with insulin and insulin resistance level in offspring at the age of 2 years old, which suggests that health care providers should pay more attention and improve sleep quality of women in the third trimester of pregnancy, thereby improving the metabolic outcome of the offspring.

Key words: late pregnancy, sleep, offspring, insulin, insulin resistance