关键词: 绒毛膜羊膜炎, 脐带炎, 早产儿, 疾病

Abstract: Objective To investigate the relationship between chorioamnionitis or funisitis and diseases in preterm infants with gestational age less than 34 weeks. Method A total of 151 premature infants with gestational ages less than 34 weeks were enrolled.According to placental pathology,subjects were divided into CA(-)FV(-)group,CA(+)FV(-)group,and CA(+)FV(+)group.Incidence of diseases and the infection parameters among three groups were compared. Result The incidence of diseases increased with the progress of inflammation,and the incidence rates of pneumonia,respiratory distress syndreme (RDS),intracranial hemorrhage,and necrotizing enterocolitis (NEC) in three groups were significantly different (P<0.05).Prenatal fever,white blood cell count(WBC) of prenatal maternal infection,C reactive protein (CRP) and neonatal calcitonin peptide(PCT)were significantly different (P<0.05).With the increasing of the infection index,tissue type chorioamnionitis and funisitis increased gradually,while the difference of the prenatal N% and infection index of preterm infants was not significant (P>0.05). Conclusion Exposure to chorioamnionitis or funisitis will lead to higher incidence of organ damage in preterm infants of gestational age less than 34 weeks.Also,the incidence rates of pneumonia,RDS,intracranial hemorrhage,NEC are closely correlated with chorioamnionitis or funisitis.The levels of WBC,C reactive protein(CRP) and neonatal calcitonin peptide(PCT)could be an indicator to predict the occurrence of chorioamnionitis or funisitis in preterm infants.

Key words: chorioamnionitis, funisitis, premature, diseases