关键词: 性早熟, kisspeptin, 神经激肽B, 强啡肽

Abstract: Objective To investigate the change of plasma concentrations of kisspeptin,neurokinin B(NKB) and dynorphin(Dyn) in girls with idiopathic central precocious puberty(ICPP). Methods Totally 50 girls with ICPP before treatment were enrolled in this study from January 2016 to January 2017 in Qilu hospital, shandong University. The changes of sexual development situation and plasma kisspeptin,NKB and dynorphin concentrations between girls with ICPP and normal healthy girls before and after treatment were analyzed. Results There were significant differences on bone age,bone age/age of child,standard deviation score of height(SDS),basal luteinizing hormone(B-LH),basal follicle stimulating hormone(B-FSH),estradiol(E2),kisspeptin and NKB between ICPP group and healthy control group before treatment(P<0.01). After 6 months treatment,the levels of B-LH,peaking LH(P-LH),B-FSH,peaking FSH(P-FSH),P-LH/ P-FSH,E2,kisspeptin and NKB significantly decreased compared with those before treatment(P<0.01). However,difference on the above indexes were not found significant between 6 months and 12 months after treatment in ICPP girls(P>0.05),and there was no significant difference on the level of Dyn among threee groups(P>0.05). After treatment with gonadotropin releasing hormone analogue(GnRHa),the sexual development of ICPP girls was significantly controlled within 3 months,and the sexual development did not significantly improved at the end of 12 months. Moreover,kisspeptin level was positively correlated with NKB,P-LH,P-LH/P-FSH and E2(P<0.05),and NKB level was also positively correlated with kisspeptin,P-LH,P-LH/P-FSH and E2,too(P<0.05). Conclusion Kisspeptin and NKB play an important role in the pathogenesis of ICPP,and may become an effective indicator for monitoring children'sexual development and evaluating therapeutic effect of ICPP children.

Key words: precocious puberty, kisspeptin, neurokinin B, dynorphin