出生体重与婴幼儿体格发育及糖脂代谢的相关性分析

doi:10.11852/zgetbjzz2018-0849

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (7): 724-728.DOI: 10.11852/zgetbjzz2018-0849

出生体重与婴幼儿体格发育及糖脂代谢的相关性分析

吴巧玲¹, 余文¹, 龚春丹², 张丹³, 赵正言⁴, 彭咏梅^2,3

1 上海交通大学附属国际和平妇幼保健院,上海 200030;
2 上海市妇幼保健中心,上海 200062;
3 复旦大学附属儿科医院,上海 201102;
4 浙江大学医学院附属儿童医院,浙江杭州 310050

收稿日期:2018-08-22 发布日期:2019-07-10 出版日期:2019-07-10
通讯作者: 彭咏梅,E-mail:ympeng@fudan.edu.cn;余文,E-mail:yuwencd@163.com
作者简介:吴巧玲(1985-),女,四川人,主治医师,博士学位,主要研究方向为儿童营养与生长发育。
基金资助:
国家科技部“十一五”支撑计划项目(2009BAI80B03)

Analysis on the correlation of birth weight with physical development and glycolipid metabolism during infancy

WU Qiao-ling¹, YU Wen¹, GONG Chun-dan², ZHANG Dan³, ZHAO Zheng-yan⁴, PENG Yong-mei^2,3

1 Department of Child Health Care and Rehabilitation,International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University,Shanghai 200030,China;
2 Shanghai Center for Women and Child′s Health,Shanghai 200062,China;
3 Department of Child Health Care,Children′s Hospital of Fudan University,Shanghai 201102,China;
4 Department of Child Health Care,Children′s Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310050,China

Received:2018-08-22 Online:2019-07-10 Published:2019-07-10
Contact: PENG Yong-mei,E-mail:ympeng@fudan.edu.cn; YU Wen,E-mail:yuwencd@163.com

摘要/Abstract

摘要： 目的探讨出生体重(BW)与婴幼儿体格发育及糖脂代谢的相关性,分析婴儿期体格追赶生长的影响因素。方法随机纳入母子配对样本1 064例,收集婴幼儿出生前后的一般情况、0~18月龄体格及喂养数据。检测脐血及18月龄静脉血糖脂代谢指标。结果新生儿BW与血清超敏C反应蛋白(hCRP)显著正相关,与甘油三酯(TG)显著负相关,且仅与女婴脂蛋白a(Lpa)显著正相关(P<0.05)。18月龄时,BW与男童空腹血糖(GLU)及女童高密度脂蛋白胆固醇(HDL-c)显著负相关(P<0.05)。BW与 6月龄内体格增长显著负相关,低出生体重(LBW)在6月龄内的体格追赶生长幅度显著较高(P<0.01)。使婴儿6月龄体重指数Z分值(BMIZ)追赶生长加快的因素是BW过低、进食泥状及汁装辅食,使其减慢的因素是父亲高血压、吃奶时间较长、进食鱼虾类频率较高、家庭年收入较高。结论 BW过高或过低均对糖脂代谢产生不利影响。LBW婴儿6月龄内增长幅度显著较高,可能与远期代谢综合征(MS)风险增加有关

关键词: 婴幼儿, 出生体重, 体格发育, 糖脂代谢, 代谢综合征

Abstract: Objective To investigate the correlation of birth weight (BW) with children′s physical development and glycolipid metabolism during infancy,and to analyze the influencing factors of infant catch-up growth. Methods A total of 1 064 mother-child pairs were randomly recruited and the perinatal baseline information,anthropometric indexes and feeding data of children aged 0 to 18 months were recorded. The neonatal cord blood and the venous blood of 18-month-old children were tested for glycolipid metabolism indexes. Results BW of newborns presented significantly positive correlation with serum high sensitivity C-reactive protein (hCRP) but negative correlation with triglyceride (TG) ,and positive correlation between BW with lipoprotein a (Lpa) was found only in female infants (P<0.05). At 18 months old,negative correlation was found between BW with fasting glucose (GLU) in male and high density lipoprotein cholesterol (HDL-c) in female (P<0.05). Within 6 months old,significantly negative correlation between BW and children′s physical development was detected,and low birth weight (LBW) infants showed significantly more physical catch-up growth (P<0.01). Lower BW,mashed and fluid supplementary food were found to be promoting factors of body mass index Z score(BMIZ)catch-up growth within 6 months old,while paternal hypertension,eating slowly,higher fish-species consumption frequency and higher family income were shown to be weakening factors for BMIZ catch-up growth. Conclusions Extremely high or low of BW is likely to have adverse effects on glycolipid metabolism. Significant higher BMIZ catch-up growth in LBW infants within 6 months old may increase the risk of metabolic syndrome (MS) in adulthood

Key words: infants, birth weight, physical growth, glycolipid metabolism, metabolic syndrome

中图分类号:

R174

吴巧玲, 余文, 龚春丹, 张丹, 赵正言, 彭咏梅. 出生体重与婴幼儿体格发育及糖脂代谢的相关性分析[J]. 中国儿童保健杂志, 2019, 27(7): 724-728.

WU Qiao-ling, YU Wen, GONG Chun-dan, ZHANG Dan, ZHAO Zheng-yan, PENG Yong-mei. Analysis on the correlation of birth weight with physical development and glycolipid metabolism during infancy[J]. journal1, 2019, 27(7): 724-728.

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出生体重与婴幼儿体格发育及糖脂代谢的相关性分析

Analysis on the correlation of birth weight with physical development and glycolipid metabolism during infancy

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