关键词: 双酚A, 学龄儿童, 尿液, 检出率, 影响因素

Abstract: Objective To evaluate current status and influencing factors of urinary bisphenol-A (BPA) among children aged 6 to 8 years in Xiamen,in order to provide reference for the assessment and prevention of BPA exposure. Methods Questionnaires and spot urine samples were collected from 253 primary school students aged 6 to 8 years in Xiamen from September to October in 2017.Urinary BPA concentration was determined by Triple Quadurupole Liquid Chromatography-Tandem mass Spectrometry (LC-MS/MS) and its potential risk factors were analyzed through single-factor and multi-factors statistics methods. Results The detection rate of urinary BPA in 253 students was 89.33%,and the median concentration was 1.55 ng/ml,the interquartile range was 0.39-3.95 ng/ml.After adjusting gender,age,family socio-economic status and education level of parents,Logistic regression analysis indicated that the detection rate of BPA in 6-year-old children was higher than those in children at the age of 7 years(P=0.031) and 8 years(P=0.007).Moreover,using plastic cups for drinking water was a risk factor for BPA exposure (OR=2.640,95%CI: 1.039-6.707,P=0.041). Conclusions Children aged 6 to 8 years in Xiamen may be widely exposed to BPA,and children with lower age are more vulnerable to BPA exposure.Moreover,the use of plastic cups for drinking water may be one of the main risk factors of BPA exposure for school-age children.

Key words: bisphenol-A, school-age children, urine, detection rate, influencing factors