关键词: 小肠型脂肪酸结合蛋白, 多态性, 儿童, 单纯性肥胖

Abstract: Objective To investigate the association between fatty acid binding protein 2(FABP2)G54A polymorphism and childhood simple obesity. Methods A total of 80 simple obesity children from Chongqing No.3 and No.4 People Hospitals of Chongqing City were enrolled in obesity group, and 80 normal healthy children were selected as the control group according to the 1∶1 pairings from January 2014 to February 2017. PCR technology was used to detect FABP2 gene G54A polymorphism in both groups.Blood biochemical indicators were detected and compared.And the relationship between FABP2 gene G54A gene polymorphism and childhood simple obesity was analyzed by Logistic regression analysis. Results There were no significant differences on serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG) and fatty acid (FFA) between obesity group and control group (P>0.05). The serum levels of triglyceride (TG), leptin, cortisol and visceral fat specific serine protease inhibitors in obesity group were significantly higher than those in control group (P<0.05),but the adiponectin (APN) level in obesity group was significantly lower than that in control group (P<0.05). The FABP2 gene G54A allele frequency of A (43.13%) in obesity group was significantly higher than that in control group (27.50%) (P<0.05); Serum TG(OR＝1.528,95%CI:1.221~4.007), leptin(OR＝1.694,95%CI:1.381~4.214), increased cortisol levels(OR＝1.664,95%CI:1.360~4.815) and allele A(OR＝1.773,95%CI:1.468~5.598), as well as the decreased level of APN(OR＝0.728,95%CI:0.517~0.839) were risk factors for simple obesity in children (P<0.05). Conclusion The G54A polymorphism of FABP2 gene A is an independent risk factor for simple obesity in children.

Key words: small intestinal fatty acid binding protein, polymorphism, children, simple obesity