关键词: 新生儿, 黄疸, 光疗, 胆红素

Abstract: Objective To determine whether transcutaneous bilirubin measurements(TcB) before and during phototherapy consist with total serum bilirubin(TSB) levels,in order to provide reference for the bilirubin monitoring during phototherapy. Methods A prospective observational study was conducted on full-term neonates requiring phototherapy and TSB measurements from March 2017 to May 2018.TcB measurement was collected within 3 minutes of blood for TSB measurements.The consistency of TcB and TSB was analyzed by Bland-Altman method. Results A total of 239 neonates were included,with the gestational age of (38.3±1.2) weeks and birth weight of (3.1±0.23)kg.Before starting phototherapy,the levels of TSB and TcB were (221.3±32.8) μmol/L and (227.5±33.9)μmol/L,respectively.During phototherapy,the levels of TSB and TcB were (188.6±35.2) μmol/L and (185.9±32.6) μmol/L,respectively.The Bland-Altman analysis demonstrated that before starting phototherapy the mean difference between TSB and TcB was (6.7±21.4) μmol/L (95% CI:-27.9-41.2)μmol/L,which was(-2.7±20.7)μmol/L (95% CI:-42.4-37.1)μmol/L during phototherapy. Conclusion The consistency between TcB measurement and TSB measurement is satisfying,indicating that both of them can be used to monitor bilirubin levels during phototherapy in jaundiced term infants.

Key words: neonate, jaundice, phototherapy, bilirubin